INTRODUCTION Chordoma is a rare malignant tumour with an incidence of metastasis of less than 10 percent. Usually arising from clivus its posterior extension may involve the brainstem before presenting as nasal mass and obstruction. Surgery is the main mode of treatment with adjuvant radiotherapy. However surgery is rarely possible for a large intracranial lesion. CASE PRESENTATION We report ...

Chordomas are primary low grade malignant tumors of bone that usually arise within both ends of axial skeleton. The Notochord is a midline, ectoderm-derived structure that defines the phylum of chordates. Chordomas may pose difficult diagnostic challenges when encountered in secondary locations, such as lungs or other parenchymatous organs. We report the cytologic findings of a metastatic chord...

The author of the above mentioned paper have noticed a mistake in Table 1 following publication and wish to make the following correction. The reference for the lapatinib study should be 36 (Stacchiotti S, Tamborini E, Lo Vullo S, et al. Phase II study on lapatinib in advanced EGFR-positive chordoma. Ann Oncol. 2013;24:1931–6), and the reference for the 9-nitro-camptothecin study should be 43 (...

the clivus is the surface of a portion of the occipital and sphenoid bones in the base of the skull. (1)it is surrounded by the neurovascular structures of the brainstem, as well as internal carotid arteries. tumors of the clivus can be benign (chordoma)or malignant (chondrosarcoma).(2) chordomas are rare, aggressive, slow-growing, invasive, and locally destructive tumors that arise from the no...

introduction: notochord. although histologically benign, these tumors are locally aggressiveand present significant managment challenges . there arew some studies onevaluated the location, age and gender of the patients with chordoma in tworeferral centers in tehran.chordoma cases but there was no study about iranian cases. in this study weskull base chordomas are rare neoplasms arising from th...

OBJECT Chordoma cells can generate solid-like tumors in xenograft models that express some molecular characteristics of the parent tumor, including positivity for brachyury and cytokeratins. However, there is a dearth of molecular markers that relate to chordoma tumor growth, as well as the cell lines needed to advance treatment. The objective in this study was to isolate a novel primary chordo...

The authors present a case of a 29-year-old man who developed rapidly progressive cranial nerve palsies and a right hemiparesis secondary to a pontine hemorrhage. The rare but correct diagnosis of a clival chordoma which had invaded the brain stem and subsequently hemorrhaged was based on computed tomography and magnetic resonance imaging. The diagnosis was confirmed at surgery when the patient...

Dra. Rita Delgado – Rua Borges Lagoa 1080 / 307 04038-002 São Paulo SP Brasil. E-mail: [email protected] Chordomas are slow-growing tumors with aggressive local behavior that probably originate from embryonic remnants of the notochord. This is a midline structure along the neural tube that presents involution and fragmentation as ossification of the axial skeleton occurs, in such way that i...

The endoscopic approach has been recommended as a primary option for treating chordomas, and it is associated with better resection rates fewer surgical complications than transcranial surgery. This review aimed to assess the long-term consequences evidence in current literature regarding approach's efficacy skull-base chordoma children. A systematic was conducted based on PubMed, Web of Scienc...