There is actually no consensus about the possibility that in some instances, obesity may be a benign metabolically healthy (MH) condition as opposed to a normal-weight but metabolically unhealthy (MUH) state. The aim of this study was to characterize MH condition and to investigate possible associations with metabolic and cardiovascular complications. One thousand nineteen people (range of age ...

Félétou, Michel, and Paul M. Vanhoutte. Endothelial dysfunction: a multifaceted disorder. Am J Physiol Heart Circ Physiol 291: H985–H1002, 2006. First published April 21, 2006; doi:10.1152/ajpheart.00292.2006.—Endothelial cells synthesize and release various factors that regulate angiogenesis, inflammatory responses, hemostasis, as well as vascular tone and permeability. Endothelial dysfunction...

A beneficial influence of antimalarials on lipid profile of systemic lupus erythematosus (SLE) patients has been recently claimed. In this cross-sectional study, we evaluated the effect of chloroquine on cholesterol levels of a Brazilian population with SLE. Sixty patients were studied, 95% females. Mean age was 48.7 years (SD 13.3 years). Overweight or obesity was documented in 27 cases (45%)....

AIMS Hypolipidemic drugs are prescribed in the most of cases for the treatment of cardiovascular diseases. Several studies have showed that the gut microbiota is able to regulate the host cholesterol metabolism. This study aimed to investigate the potential impact of hypolipidemic drugs on the gut microbiota in mice, and to correlate it to the regulation of cholesterol metabolism. MAIN METHOD...

The present study was under taken to establish the potential of Sida cordifolia Linn. (Family—Malvaceae) as anti-hyperglycemic and anti-hypercholesterolemic agent. The effects of the methanol and aqueous extracts on oral glucose tolerance test (OGTT) as well as effect of the aqueous extract (AE) on Streptozotocin (STZ)-induced diabetic model were studied. Anti-diabetic activity was compared wit...

Objective: The present study was designed to determine in rats fed high cholesterol diet whether serum cholesterol concentration and its distribution in lipoprotein fractions could be improved by sardine (Sardina pilchardus) and sardinelle (Sardinella aurita) protein hydrolysates. In addition, lipid peroxidation in different lipoprotein fractions and in two target tissues of atherosclosis and t...

In the modern scientific world, it has been proven that non-alcoholic fatty liver disease (NAFLD) is a marker of risk cardiovascular (CV) events, and therefore, attention control factors for CV diseases important. Considering prevalence atherogenic dyslipidemias their effect on development thrombotic complications in patients with NAFLD, important to understand role hemostatic blood activity. T...

The aim of the study was to ascertain whether the A-204C polymorphism in the cholesterol 7 -hydroxylase (CYP7A1) gene plays any role in determining LDL-cholesterol (LDL-C) concentration responsiveness to a high-fat diet. The concentrations of total cholesterol and LDL-cholesterol were measured in eleven healthy men (age: 30.9+/-3.2 years; BMI: 24.9+/-2.7 kg/m(2);;) who were homozygous for eithe...