The aim of the present study was to compare the effects of atorvastatin and pravastatin on lipid parameters and the concentration of malondialdehyde-modified low-density lipoprotein (MDA-LDL) in hypercholesterolemic patients. A total of 17 patients (10 men, 7 women; mean age, 68+/-9 years) who were indicated for drug therapy based on the National Cholesterol Education Program II underwent an 8-...

OBJECTIVE The purpose of this study was to assess the relationship between adherence to statin therapy and LDL cholesterol goal achievement in patients with diabetes and dyslipidemia. RESEARCH DESIGN AND METHODS The records of patients being medically treated for dyslipidemia in a managed care diabetes program from January 2001 to December 2002 were used to assess LDL cholesterol goal attainm...

1. Hepatic uptake of low-density lipoprotein (LDL) in parenchymal cells and non-parenchymal cells was studied in control-fed and cholesterol-fed rabbits after intravenous injection of radioiodinated native LDL (125I-TC-LDL) and methylated LDL (131I-TC-MetLDL). 2. LDL was taken up by rabbit liver parenchymal cells, as well as by endothelial and Kupffer cells. Parenchymal cells, however, were res...

Injectable DMPA contraception can cause changes in lipoprotein metabolism. Changes fat metabolism occur because of the hormonal influence progesterone, causing disruption balance lipid profiles body. The change serum profile (trgliseride, total cholesterol, HDL and LDL) long-term use is a risk factor for atherosclerosis cardiovascular disease. purpose this study was to look at description 3 mon...

The effects of feeding cholesterol, sitosterol, and lovastatin on cholesterol absorption, biosynthesis, esterification, and LDL receptor function were examined in the rat jejunal mucosa. Cholesterol absorption was measured by the dual-isotope plasma ratio method; the rate-limiting enzyme of cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, was measured as tota...

The aim of the study was to ascertain whether the A-204C polymorphism in the cholesterol 7 -hydroxylase (CYP7A1) gene plays any role in determining LDL-cholesterol (LDL-C) concentration responsiveness to a high-fat diet. The concentrations of total cholesterol and LDL-cholesterol were measured in eleven healthy men (age: 30.9+/-3.2 years; BMI: 24.9+/-2.7 kg/m(2);;) who were homozygous for eithe...

BACKGROUND AND OBJECTIVES The inhibition of cholesterol absorption by ezetimibe increases cholesterol synthesis. The effect of inhibition of cholesterol synthesis on cholesterol absorption is controversial. The influence of these interactions on cholesterol levels is unknown. We investigated on the extent to which cholesterol levels were affected by the reaction of one pathway to the inhibition...

Background: Climate change is a serious threat to human wellbeing and development. Global reduction of meat intake key addressing climate other modern sustainability challenges. Plant-based mycoprotein-based substitutes are predicted play role in the intake; however, their impact on health unclear. The main objective this meta-analysis was assess short-term effects important cardiometabolic bio...

Several studies have shown that increased levels of low-density lipoprotein (LDL) cholesterol predict cardiovascular events. The Adult Treatment Panel II (ATP II) introduced the principle of therapeutic lifestyle changes, including plant sterols/stanols for the management of LDL cholesterol. Plant sterols and stanols in fat matrices effectively lower LDL cholesterol levels in hypercholesterolem...

High serum cholesterol is a major risk factor for coronary heart disease (CHD), and most cholesterol in serum circulates with low density lipoproteins (LDLs). These lipoproteins are macromolecular complexes containing a core of nonpolar lipids — mainly cholesterol ester—and a surface coat of unesterified cholesterol, phospholipids, and apolipoprotein (apo) B-100. Many investigators believe that...