linear and whorled nevoid hypermelanosis. J Eur Acad Dermatol Venereol. 2005;19:638--9. 4. Cho E, Cho SH, Lee JD. Progressive cribriform and zosteriform hyperpigmentation: a clinicopathologic study. Int J Dermatol. 2012;51:399--405. 5. Iijima S, Naito Y, Naito S, Uyeno K. Reticulate hyperpigmentation distributed in a zosteriform fashion: a new clinical type of hyperpigmentation. Br J Dermatol. ...

The me tabo l i sm of radioact ively labelled D-glucose, L-glutamine, and L-glutamate has been determined in a g l y c o l y t i c mu t an t of C h i n e s e h a m s t e r ovary cells, R l . I . 7 , and in its parent, CHO-K1. The complete oxidation of glucose via the TCA-cycle is negligible in both cell types, but there is significant oxidation of carbon-1. CHO-K1 cells derive most of their ene...

MiR-7 acts as a tumour suppressor in many cancers and abrogates proliferation of CHO cells in culture. In this study we demonstrate that miR-7 targets key regulators of the G1 to S phase transition, including Skp2 and Psme3, to promote increased levels of p27(KIP) and temporary growth arrest of CHO cells in the G1 phase. Simultaneously, the down-regulation of DNA repair-specific proteins via mi...

background although magnetic resonance spectroscopy (mrs) has been shown as an effective diagnostic tool in distinguishing inflammation from neoplasm in cystic brain lesions, the optimum approach in selecting the portions of lesions in mrs and the possible effects of different times of echoes (tes) remains unknown. objectives to determine the most effective te in diagnosing neoplastic lesions b...

Initial host defense to bacterial infection is executed by innate immunity, and therefore the main goal of this study was to examine the contribution of Toll-like receptors (TLRs) during Brucella abortus infection. CHO reporter cell lines transfected with CD14 and TLRs showed that B. abortus triggers both TLR2 and TLR4. In contrast, lipopolysaccharide (LPS) and lipid A derived from Brucella rou...

background: radio-adaptive response and bystander effects are known phenomena occurring in cells following exposure to ionizing radiation (ir). in this study we examined possible radio-adaptation of lymphocytes following bystander effects induced by cho-k1 cells. materials and methods: whole blood and cho-k1 cells were cultured in rpmi-1640 complete medium. cells were separately irradiated with...

objective: to study the mechanisms involved in amyloid formation processes, we made a mammalian cell culture model of amylin aggregation and characterized its properties. materials and methods: amyloid fibrils were extracted from cho cells and binding affinity to thioflavin t and congo red was investigated. then the apple-green birefringence of extracted fibrils was detected under polarized li...

Short-term alterations in dietary carbohydrate (CHO) energy are known to alter whole-body fuel selection in humans, but the metabolic mechanisms remain unknown. We used stable isotope-mass spectrometric methods with indirect calorimetry in normal subjects to quantify the metabolic response to six dietary phases (5 d each), ranging from 50% surplus CHO (+50% CHO) to 50% deficient CHO (-50% CHO),...