The roots of 7-d seedlings of two winter wheat cultivars differing in frost resistance were used to study changes in lectin activity using the inhibitor of microtubule polymerization oryzalin (15 μM) in unhardened (23oC) and hardened (2–3oC, 3–7 d) plants. Plants were grown with the antagonist of calmodulin, chlorpromazine (250 μM) or without chlorpromazine in medium. It was shown that the dyna...

Chlorpromazine is a phenothiazine antipsychotic which is often used in hospice and palliative care to treat hiccups, delirium, and nausea. With the discontinuation of the commercial oral solution concentrate, there is a need to prepare this product by extemporaneous compounding. This study was initiated to identify an easy-to-prepare formulation for the compounding pharmacist. A stability study...

Numerous reports including Courvoisier et al. (1) have been made of the pharmacolo gical studies on chlorpromazine. The action of chlorpromazine on the central nervous system has been studied in reference to electroencephalography and evoked potentials from the brain of animal. Although the action mechanism of the drug has been well explained, much seems still left unclarified. The most conspic...

The purpose of this paper is to focus on the short-term effects of chlorpromazine on erythrocytes because it is reported that the drug, unstable in plasma but more stable in erythrocytes, interacts with erythrocyte membranes, membrane lipids, and hemoglobin. There is a rich literature about the side and therapeutic effects or complications due to chlorpromazine, but most of these studies explor...

Previous investigations have demonstrated the ability of atropine and chlorpromazine pretreatment to increase intravenous cocaine self-administration in rhesus monkeys. These results were interpreted as resulting from either an antagonism of cocaine's reinforcing effect or an effect of cocaine which may interfere with its self-administration. The generality of the postulated drug antagonism was...

Liver ischemia in intact rats is associated with a series of alterations in mitochondrial structure and function that include: a complete loss of respiratory control; a loss of adenine nucleotide translocase activity; decreases in, at least, the heme portions of cytochromes aa and c + cl; a decrease in dinitrophenolactivated ATPase; a loss of the ability of dinitrophenol to stimulate 02 uptake;...

1. Phosphatidate phosphohydrolase from the particle-free supernatant of rat liver was assayed by using emulsions of phosphatidate as substrate. 2. The inhibition of the phosphohydrolase by chlorpromazine was of a competitive type with respect to phosphatidate. The potency of various amphiphilic cationic drugs as inhibitors of this reaction was related to their partition coefficients into a phos...

Combination therapy has proven successful in treating a wide variety of aggressive human cancers. Historically, combination treatments have been discovered through serendipity or lengthy trials using known anticancer agents with similar indications. We have used combination high-throughput screening to discover the unexpected synergistic combination of an antiparasitic agent, pentamidine, and a...

Escherichia coli heat-stable enterotoxin (ST) appears to cause intestinal fluid secretion by activating intestinal particulate guanylate cyclase. Recent studies suggest that chlorpromazine and quinacrine reduce the intestinal secretory response to ST and activation of guanylate cyclase by ST. We have examined the effects of lanthanum chloride, another agent that has been shown to inhibit calciu...

The influence of single and repeated doses of morphine, pentazocine, and chlorpromazine on the latent time of cortical evoked potentials was observed in rats. The evoked potentials were induced by electrical stimulation of the sciatic nerve under the condition of curarization and artificial respiration. The evoked potential consisted of 4 phases. The latent time of the N2 component was prolonge...