A 62-year-old man was admitted to hospital 10 times over 12 years because of pyrexia of unknown origin. Hypothalamic hypopituitarism was diagnosed by dynamic tests including clomiphene, LRH, TRH and chlorpromazine stimulation. Lack of ACTH was demonstrated by long and short tetracosactrin tests. The aetiology of the disorder was believed to be previous encephalitis. Following substitution thera...

OBJECTIVE Determine the effect of a matrix metalloproteinase inhibitor (MMPi) and angiotensin converting enzyme inhibitor (ACEi) on collagen, MMP, tissue inhibitors of MMPs (TIMPs) expression in the spontaneously hypertensive heart failure (SHHF) rat. METHODS Six groups were tested: normotensive 9- and 13-month-old Wistar-Furth (WF) rats, 9-month-old SHHFs (compensatory hypertrophy), 13-month...

The MICs of several antibiotics (both hydrophobic and hydrophilic) which penetrate very poorly into intact Escherichia coli cells were found to be 2- to 10-fold decreased in the presence of low doses of various local anesthetics (procaine, dibucaine, tetracaine, chlorpromazine, and quinine). The concentrations of anesthetics necessary for this effect have no adverse effect on cell growth and ar...

This study has selected the medium-chain saturated fatty acid pelargonic as raw material for first time, and added surface catalyst Tween 80 to aqueous solution form acid–Tween composite vesicles by a tension method. The compound vesicle was used encapsulate five heterocyclic drugs (cefazolin sodium, chlorpromazine hydrochloride, gemcitabine metronidazole, isoniazid), all of which have disadvan...

Promethazine (phenergan) has two methyl groups, which in these derivatives are associated with strong antihistaminic power, while chlorpromazine is a propylamine phenothiazine, which has more marked central nervous system effects but only one-hundredth of the antihistamine potency of promezathine. The Department of Pharmacology at Oxford has pointed out (Burns, 1948; Burns and Dutta, 1948; Dews...

Comparative Effects of Diaxepam and Midazolam on Paraoxon Toxicity in Rats. KRUTAKKROL, H., AND DOMINO, E. F. (1985). Toxicol. Appl. Pharmacol. 81,545-550. The present study was undertaken to compare the effectiveness of a new water-soluble benzodiazepine, midazolam, to diazepam, both administered im for protection against diethyl-pnitrophenyl phosphate (paraoxon) toxicity. Adult male Sprague-D...

Patients were randomly allocated to one of two groups; intravenous or epidural analgesia, with twenty patients in each group. General anesthesia was induced with thiopentone 5-6 mgkg-1 and maintained with 0.8-1.0% isoflurane and 66% nitrous oxide in 33% O2. The trachea was intubated after administration of vecuronium 0.1 mgkg-1. Patients in the epidural analgesia groups then received, by random...

In India, agricultural soil has been deteriorated by various on-going practices involving application of chemical fertilizers, pesticides and effluents. Presently, Amritsar (Punjab), an agricultural land, is undergoing rigorous cultivation of wheat and rice crops which consequently increased the application of chemical pesticides and fertilizers for high yield. These agricultural practices are ...

Lichens are widely used to assess the atmospheric pollution by heavy metals and radionuclides. However, few studies are available in publications on using lichens to qualitatively assess the atmospheric pollution levels. The paper presents research results applying epiphytic lichens as bio-monitors of quantitative atmospheric contamination with uranium. The observations were conducted during 2....