The immobilization of laccase (Aspergillus sp.) on chitosan by cross-linking and its application in bioconversion of phenolic compounds in batch reactors were studied. Investigation was performed using laccase immobilized via chemical cross-linking due to the higher enzymatic operational stability of this method as compared to immobilization via physical adsorption. To assess the influence of d...

Previous work had shown that the immunogenicity of conjugate vaccine against group C meningococci (CRM-MenC) is enhanced when it is delivered intranasally (inl) with mucosal adjuvants, such as mutants of the Escherichia coli enterotoxin (LT), and with delivery systems such as chitosan derivatives. We show, in mice, that the concomitant use of limiting doses of the fully nontoxic LTK63 mutant as...

This work focused on studying the physicochemical and antioxidant properties changes of varying molecular weight (Mw) chitosan-depolymerization products (CDP)-based films occurring after crosslinking by heat-treatment Maillard reaction (MR). Based color browning index, an enhancement was observed treatment at 90 °C with a reduction in their water content, solubility contact angle. Brown MR were...

Chitosan derivatives substituted with benzophenone groups that can be cross-linked by ultraviolet light were synthesized as coatings for PEEK substrates used in the construction of lumbar cages. The IC90 values benzophenone-modified chitosan polymers solution before crosslinking same range those reported native chitosan. resulting hydrogel surface after exhibited excellent antimicrobial propert...

Researchers always give attention to find a better polymeric substance for antimicrobial properties development on jute fabric. Because of non-toxic, biodegradable nature, as well absorption coefficient capabilities, chitosan is used agent. But has narrow solubility range and also adhesive effect fabric that makes difficult further use especially in medical textile. By creating derivatives such...

7-Ethyl-10-hydroxycamptothecin (SN38), an active metabolite of irinotecan (CPT-11), is a remarkably potent antitumor agent. The clinical application of SN38 has been extremely restricted by its insolubility in water. In this study, we successfully synthesized two macromolecular prodrugs of SN38 with different conjugate positions (chitosan-(C10-OH)SN38 and chitosan-(C20-OH)SN38) to improve the w...

The current study aims to investigate the effect of chitosan derivatives on the intestinal absorption and bioavailabilities of forsythoside A (FTA) and Chlorogenic acid (CHA), the major active components in Flos Lonicerae-Fructus Forsythiae herb couple. Biopharmaceutics and pharmacokinetics properties of the two compounds have been characterized in vitro, in situ as well as in rats. Based on th...

Nitrogenated derivatives of cellulose, and namely chitin and chitosan, are of commercial interest because of their antibacterial activity, biocompatibility, biodegradability and sorption ability. Structure and some physicochemical properties of these derivatives have been studied by methods of wide-angle X-ray scattering (WAXS), microcalorimetry and sorption. To determine the crystallinity degr...

To elucidate the structure-antioxidant activity relationships of chitosan gallate (CG), a series of CG derivatives with different degrees of substitution (DS's) and molecular weights (MWs) were synthesized from chitosan (CS) and gallic acid (GA) via a free radical graft reaction. A higher MW led to a lower DS of CG. The structures of CG were characterized by FT-IR and ¹H NMR, and results showed...