A chiral liquid chromatographic method is developed for the enantiomeric resolution of Linezolid, (S)(-)-N-[[-3-(3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide, an antibiotic in bulk drugs. The enantiomers of Linezolid are resolved on a Chiralcel OJ-RH column using a mobile phase system containing 150mM di-sodium hydrogen phosphate buffer (pH 4.5)-acetonitrile (86:14,...

In this study, brush type and polymer stationary phases were prepared based on (S)-N-(1-phenylethyl) acrylamide, the polymeric phase demonstrated superior chiral recognition ability. The two synthesized by strategies, one was “grafting from” method, which obtained CSP initiating monomer polymerization surface of 3-methacrylatepropyl silica gel, other to”, fixed copolymer acrylamide trimethoxysi...

Charged cyclodextrin (CD) derivatives were used as chiral selectors in electrokinetic chromatography (EKC) for the chiral separation of highlyhydrophobic neutral racemates such as atropisomeric polychlorinated biphenyls (PCBs). -CD-phosphated, -CD sulfated, succinylated-CD (Succ-CD) and succinylated-CD (Succ-CD) were used as anionic CDs. As cationic CD, 6-monodeoxy-6-monoamino-CD ( -CD-NH2) was...

Porous zirconia particles are very robust material and have received considerable attention as a stationary phase support for HPLC. We prepared cellulose dimethylphenylcarbamate-bonded carbon-clad zirconia (CDMPCCZ) as a chiral stationary phase (CSP) for separation of enantiomers of a set of 14 racemic compounds in normal phase (NP) and reversed-phase (RP) liquid chromatography. Retention and e...

Running Title: Chiral analysis of microalgae amino acids by MEKC-LIF ABSTRACT In this work, a chiral and a non-chiral micellar electrokinetic chromatography with laser-induced fluorescence detection (MEKC-LIF) have been combined to identify and quantify a group of D-and L-amino acids (D/L-aa) in different microalgae samples. The combination of the non-chiral and chiral-MEKC-LIF methods made eas...

The enantiomers of the chiral compound (2S, 9S)-diamino-2,9-dibenzyldeca-4,6-diynedioic acid and (2R, 9R)-diamino-2,9-dibenzyldeca-4,6-diynedioic were separated by a high-performance liquid chromatography (HPLC) method. separation α-amino acids was performed using 5µ 4.0×250 mm column, which obtained on basis sorbent with eremomycin. is silica gel (with 11 nm pore diameter surface area 300 m2/g...

experimental determination of solubility and ternary phase diagram of chiral compound are of tedious and time consuming tasks, and in many cases, there is not enough experimental data for different enantiomeric compositions to access the experimental ternary phase diagram. using thermodynamic models with predictive capability, having less dependency on experimental data, affords a great advanta...