Introduction: Acute Leukemia with Mixed Lineage phenotype (MLL) is leukemia that consists of cells characterized by mixed lineage markers, both from myeloid and lymphoid cells. The incidence this only 2-5% all acute leukemias considered to have a poor prognosis.Case Presentation: A seven-year-old girl was diagnosed MLL. results immunophenotyping showed two blast populations the expressions CD33...

Studies of childhood leukemia and the potential etiologic role of genetic variation in folate metabolism have produced conflicting findings and have often been based on small numbers. We investigated the association between polymorphisms in key folate metabolism enzymes (MTHFR 677 C>T, MTHFR 1298 A>C, SHMT1 1420 C>T, MTR 2756 A>G, TS 1494del6, and TS 28bp repeat) in 939 cases of childhood acute...

accounts for a third of all cancers in children under the age of 15, mostly affecting industrialized countries, being the B-precursor acute lymphoblastic leukemia (pB-ALL) the most common type. The disease commonly strikes young children at the age of two to five years, and is treated with aggressive chemotherapy. In recent decades, more effective treatments have boosted survival rates and redu...

Acute lymphoblastic leukemia (ALL) is recognized as a fast-developing cancer originated from blood-progenitor cells. Blasts cells are immature cells which generate white blood cells (leukocytes), and it is the malignancy of the blast cells which lead to leukemias. The bone marrow is gradually filled up with these blasts and as a result, the production of healthy blood cells will be damaged. Mal...

The objectives of this study were to examine the association between contact current exposure and the risk of childhood leukemia and to investigate the relationship between residential contact currents and magnetic fields. Indoor and outdoor contact voltage and magnetic-field measurements were collected for the diagnosis residence of 245 cases and 269 controls recruited in the Northern Californ...

The cure rate for childhood acute lymphoblastic leukemia (ALL) now exceeds 70%. This success has been achieved in part by improvements in the biologic characterization of newly diagnosed patients. Modern treatment protocols rely on this information to tailor therapy to a patient's risk of relapse. Patients with favorable genetic features, such as hyperdiploidy or the TEL-AML1 fusion, can be tre...

OBJECTIVE This study investigated the co-existence of Leishmania chagasi infection and childhood leukemia in patients naïve to treatment; this has serious clinical and epidemiological implications. METHODS The seroprevalence of L. chagasi antibodies prior to any treatment was investigated in children with clinical features of acute leukemia. Serological tests were performed in 470 samples dra...

Of all cancers in childhood (by WHO definition: O-14 year age group), leukemias constitute one of the most important groups of tumors. Our understanding of the biologic features of the childhood leukemias has increased greatly over the past decade. The ability to discern cytogenetic and molecular differences among morphologically and immunologically similar populations of leukemic cells has hel...