MOTIVATION A number of available program packages determine the significant enrichments and/or depletions of GO categories among a class of genes of interest. Whereas a correct formulation of the problem leads to a single exact null distribution, these GO tools use a large variety of statistical tests whose denominations often do not clarify the underlying P-value computations. SUMMARY We rev...

Polymorphisms in DNA double-strand break repair gene XRCC2 may play an important role in colorectal cancer etiology, specifically in disease subtypes. Associations of XRCC2 variants and colorectal cancer were investigated by tumor site and tumor instability status in a four-center collaboration including three U.K. case-control studies (Sheffield, Leeds, and Dundee) and a U.S. case-control stud...

BACKGROUND The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease. Migraine, with and without aura (MA and MO), is a prevalent and complex neurovascular disorder that may also be affected by genetically influenced hyperhomocysteinaemia. To determine whether the C677T...

The role of sense of coherence (SOC) on the relationship between adolescent school-related stress and subjective health complaints was tested with structural equation modelling. As part of the crossnational WHO-survey 'Health behaviour in school-aged children 1997/98' Norwegian representative samples of 1592 grade 6, 1534 grade 8, and 1605 grade 10 students completed measures on SOC, school-rel...

AIMS A statistical method used in ecology is adapted to characterize the degree of order in phyllotactic systems. SCOPE The test consists of subdividing a planar projection of the stem apical meristem into 16 sectors and counting the number of primordia appearing in each. By dividing the sum of squared deviations by the mean number of primordia per sector the chi-square (chi2) is obtained. Wh...

A clinical epidemiological study has been conducted as apart of research project investigating chronic exposure to solar ultraviolet radiation (UVR) as a factor contributing to the onset of age-related macular degeneration (ARMD). The study included 623 subjects older than 50 from two different geographic areas, one with high solar radiation (the island of Solta - Region 1) and the other (Zagre...

Previous rotamer libraries showed little significant clustering for asparagine chi2 or glutamine chi3 values, but none of those studies corrected amide orientations or omitted disordered side chains. The current survey used 240 proteins at /=0.4 A). All H atoms were added and optimized, and amide orientat...

BACKGROUND There is no consensus on whether closed kinetic chain (CKC) or open kinetic chain (OKC) exercises should be the intervention of choice following an anterior cruciate ligament (ACL) injury or reconstruction. METHODS A systematic search identified randomized controlled trials of OKC versus CKC exercise training in people who had undergone ACL reconstructive surgery. All published stu...

Railway track faults may lead to railway accidents and cause human financial loss. Spatial, temporal, weather elements, wear tear, ballast, loose nuts, misalignment, cracks leading accidents. Manual inspection of such defects is time-consuming prone errors. Automatic provides a fast, reliable, unbiased solution. However, highly accurate fault detection challenging due the lack public datasets, ...