We evaluated the effect of chewing on blood GLP-1 concentration by having volunteers to chew sugarless gum. Our intention was to explore the neural mechanisms regulating the secretion of glucagon-like peptide-1(GLP-1). After fasting for 12 h, 12 healthy male, non-obese volunteers (18 < BMI < 30), were asked to chew sugarless gum at a frequency of 80 times every 2 min for a total of 30 min. Bloo...

OBJECTIVE To assess the efficacy of nicotine replacement therapy in helping people to stop smoking. DESIGN Analysis of the results of 28 randomised trials of nicotine 2 mg chewing gum, six trials of nicotine 4 mg chewing gum, and six trials of nicotine transdermal patch. SUBJECTS AND SETTING Subjects were self referred (responding to advertisements or attending anti-smoking clinics) in 20 t...

The acute effects of chewing gum on cognitive performance, stress, and pain have been intensively studied in the last decade. The results have been contradicting, and replication studies proved challenging. Here, we review some of the recent findings of this topic and explore possible explanations for these discrepancies by incorporating knowledge derived from studies into oral habits and bruxi...

OBJECTIVES Chewing sugar-free gum has been shown to promote enamel remineralization. Manufacturers are now adding calcium to the gum in an approach to further promote enamel remineralization. The aim of this study was to compare the remineralization efficacy of four sugar-free chewing gums, two containing added calcium, utilizing a double-blind, randomized, crossover in situ model. METHODS Th...

Article history: Received: March 26, 2016 Revised: April 12, 2016 Accepted: April 23, 2016 Published online: April 24, 2016 The behavioral effects of chewing gum have been studied for over 80 years and much of the research has been concerned with increases in alertness and attention. Another line of research has addressed the issue of whether chewing gum reduces stress. This topic has been stud...

This study examined the effect of mouth breathing on the strength and duration of vertical effect on the posterior teeth using related functional parameters during 3 min of gum chewing in 39 nasal breathers. A CO(2) sensor was placed over the mouth to detect expiratory airflow. When no airflow was detected from the mouth throughout the recording period, the subject was considered a nasal breath...

Medicated chewing gums are defined by the European Pharmacopoeia 1 and the guidelines for pharmaceutical dosage forms as „„solid single dose preparations with a base consisting mainly of gum that are intended to be chewed but not swallowed, providing a slow steady release of the medicine contained‟‟2. It can be either used for local treatment of mouth disease or systemic delivery by direct intr...