UNLABELLED Small molecule fluorometric boron dipyrromethene probes were developed to bind hepatitis C virus-encoded NS5A protein and aid subcellular distribution studies. These molecules did not co-locate with NS5A, therefore alternative 'silent' azide reporters were used to obtain a more relevant picture of their distribution. Following pre-incubation with replicon cells, click chemistry was u...

Abnormality of fibroblast growth factor receptor (FGFR)-mediated signaling pathways were frequently found in various human malignancies, making FGFRs hot targets for cancer treatment. To address the consistent need for a new chemotype of FGFR inhibitors, here, we started with a hit structure identified from our internal hepatocyte growth factor receptor (also called c-Met) inhibitor project, an...

In order to determine the fumonisin producingisolates of the Fusarium fujikuroi species complex (FFSC), associated with infected spikes, and ear rot of grass plants, we examined 78 samples collected from Kermanshah province, Iran. Based on morphological characters, twenty two isolates assigned to the FFSC and were identified as F. proliferatum (ten isolates), F. verticillioides (seven isolates)...

Tea tree oil is an essential used for medical and health purposes consisting of a complex mixture organic compounds present in high or trace amounts. Several factors (i.e. chemotype, environmental conditions, preparation procedures) can affect the composition consequently biological properties, therefore, quality assurance key requisite to guarantee reproducibility among batches. Compliance wit...

This paper is a study of the chemical composition Hyssopus officinalis ssp. grown during three years (2017–2019) at Institute Field and Vegetable Crops Novi Sad (Vojvodina Province, Serbia). Furthermore, comparisons with ISO standards were also investigated, as well prediction model retention indices compounds from essential oils. An oil obtained by hydrodistillation analysed GC-FID GC-MS was i...

The objective of this work was to map population common juniper (Juniperus communis L.) in the territory Slovak Republic. Common is not protected by Slovakian law or authorities; therefore, there no preserve these plant populations. Biotopes consist light- heavy-density trees and shrubs. expansion its habitat also connected human involvement. loss naturally observed plants caused a change land ...