Background: Approximately 2–3% of patients undergoing advanced heart failure therapies such as left ventricular assist devices (LVAD) and orthotropic heart transplantation (OHT) have chemotherapy-related cardiomyopathy, according to analyses of large databases such as United Network for Organ Sharing (UNOS) or Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) regist...

Chemotherapy is the mainstay of cancer management, and cardiologists are increasingly confronted with referrals of patients who have suffered cardiotoxic side effects from the employed drugs [1]. Among the many cardiac morbidities encountered is that of chemotherapy-induced cardiomyopathy (CIC) phenotype, with a varying response to therapy in terms of eventual full recovery, and the time requir...

A 41-year-old woman with no significant previous medical or family history underwent a left wide local excision (WLE) and axillary node clearance for a 9-mm grade 3 IDC, node-negative breast cancer. The tumour was estrogen receptor (ER), progesterone receptor (PgR) and HER-2 negative. She received six cycles of adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC 75, ...

Introduction Primary or idiopathic cardiomyopathy is a term used for a variety of conditions affecting the heart of both animals and man with no clearly identified cause. Although the term secondary cardiomyopathy has been used with specific causative factors such as ischemic cardiomyopathy, drug induced cardiomyopathy, toxic cardiomyopathy or infectious agent induced cardiomyopathy, recent cla...

background: several competing geometric and hemodynamic factors are suggested as contributing mechanisms for functional mitral regurgitation (mr) in heart failure patients. we aimed to study the relationships between the severity of mr and the qrs duration and dyssynchrony markers in patients with ischemic or dilated cardiomyopathy. methods: w e prospectively evaluated 251 heart failure patient...

Type 2 diabetes causes structural and functional changes in the myocardium, which is called cardiomyopathy. Diabetic cardiomyopathy (DCM) is a distinct primary disorder process, independent of coronary artery disease, which leads to heart failure in diabetic patients. Also, DCM is a multifaceted disorder that is one of the leading causes of death in elderly and postmenopausal women. Menopause i...

Doxorubicin is still main drug in chemotherapy with limitation of use due to adverse drug reaction. Increased oxidative stress and alteration of nitric oxide control have been involved in cardiotoxicity of doxorubicin (DOX). A Disintegrin And Metalloproteinase (ADAMs) are transmembrane ectoproteases to regulate cell-cell and cell-matrix interactions, but role in cardiac disease is unclear. The ...

We have read with great interest the article by Klassen et al., which demonstrated that muscle strength was significantly decreased in breast cancer patients receiving anticancer treatment, compared with healthy subjects. In addition to impaired muscle strength, chemotherapyinduced cardiomyopathy has drawn much attention in this field. Intriguingly, some patients have shown dose-independent rev...

INTRODUCTION Peripartum cardiomyopathy usually presents with systolic heart failure during the last months of pregnancy and up to five months postpartum. The disease is rare and can be fatal. CASE OUTLINE We report a 30-year-old female who was diagnosed with acute myeloid leukemia, with maturation and cytogenetic finding of t(8;21)(q22;q22),del(9)(q22) in January 2004. She was treated with ch...