one-pot reaction of aldehydes or ketons with aniline derivatives was performed using nabh4 and fe3o4 magnetic nanoparticles (mnps). the optimum amount of fe3o4 mnps was 5 mol% under solvent free condition. the corresponding products were obtained in good to excellent yields. the magnetically recoverable iron oxide nanoparticles are found to be efficient for synthesis of amine derivatives. these...

An efficient synthesis of 2H-thiopyran derivatives via three-component reaction of alkyl propiolate, benzoyl isothiocyanate or its derivatives and alkyl bromides in the presence of triphenylphosphine in water at 80o C without using any catalyst in water is described. The method offers several advantages including high yields of products and an easy work-up procedure.

The powerful combination of native chemical ligation and click chemistry has been used to affect a one-pot synthesis of neoglycopeptides from propargyl-containing peptides using GalNAc-N(3) as the glycan component. A versatile chemical toolkit for the fully convergent synthesis of neoglycoproteins using click chemistry, native chemical ligation, and kinetically controlled ligation is thus demon...

Department of Organic and Macromolecula Group and Laboratory for Organic Synthesis 9000 Ghent, Belgium. E-mail: johan.winne@ Preparative Macromolecular Chemistry, Polymerchemie, Karlsruhe Institute of Tech Karlsruhe, Germany Center for Molecular Modeling, Ghent Zwijnaarde, Belgium Department of Chemistry, Bogazici Univers † Electronic supplementary information experimental details, synthesis an...

The chemistry of sulphone hydrazide has gained increase interest in both synthetic organic chemistry and biological fields and has considerable value. The therapeutic importance of these compounds is the attractive force to continue research in such a point. The present review covers the literature up to date for the synthesis, reactions and applications of such compounds. Keywords—Sulphone hyd...

We present a systematic approach to minimizing the Z-domain of protein A, a three-helix bundle (59 residues total) that binds tightly (Kd = 10 nM) to the Fc portion of an immunoglobin IgG1. Despite the fact that all the contacts seen in the x-ray structure of the complex with the IgG are derived from residues in the first two helices, when helix 3 is deleted, binding affinity is reduced > 10(5)...

The International Union of Pure and Applied Chemistry (IUPAC) and the United Nations Educational, Scientific, and Cultural Organization (UNESCO) have designated 2011 as the International Year of Chemistry (IYC2011). This special designation is meant to celebrate the achievements of chemistry and its contributions to mankind and is aimed at, under the unifying theme of “chemistry— our life, our ...

Technetium disulfide was prepared by reaction between the elements in a sealed tube at 450 °C, by reaction between Tc2(O2CCH3)5 and H2S gas in a flowing system at 450 °C and by reaction between K2TcCl6 and H2S gas in sulfuric acid. The samples were analysed by X-ray absorption fine structure (XAFS) spectroscopy.

Microbial enantioselective sulfatases http://www.aseanbiotechnology.info/Abstract/ 21022648.pdf This article describes the use of microbial sulfatases for enantio-convergent transformations to generate single enantiomer products in high yield. Chiral synthesis http://www.iccas.ac.cn/english/html/2004-8-20/ 2004820143856.htm This web page focuses on chiral synthesis with some examples of microbi...