DOI: 10.21276/sjams.2017.5.9.35 Abstract: Diabetes Mellitus (DM) is a chronic metabolic disorder affecting people worldwide, with significant morbidity and mortality caused by its micro-vascular and macro-vascular complications, affecting various vital organs and structures in humans. Glycemic variability seems to have more deleterious effects than sustained hyperglycemia on the development of ...

BACKGROUND Apart from the mean level of glycemic control, the extent of glucose excursions is another important issue to consider in type 2 diabetes mellitus (T2DM) management. Studies have showed that fluctuations of glucose seem to have more deleterious effects than sustained hyperglycemia in the development of diabetic complications as acute glucose swings activate the oxidative stress. Howe...

Aims We defined the dawn phenomenon is an increase in either insulin requirements or the plasma glucose concentration, in the absence of preceding hypoglycemia or waning insulin levels, occurring between the hours of 0400 and 0800. According to previous studies, the frequency of dawn phenomenon is reported to be approximately 54.0% inpatients with type 1 diabetes mellitus (T1DM),and the poor gl...

generally accepted target. The goal of diabetes management is to prevent diabetic complications can improve glycemic control and decreases the risk of long-term microvascular complications in diabetes, high rate of hypoglycemia becomes a risk in intensive diabetic management. The fear of hypoglycemia often leads patients to forget the fatal consequences of long-term complications to avert hypog...

OBJECTIVE The purpose of this study was to compare the numerical and clinical accuracy of four continuous glucose monitors (CGMs): Guardian, DexCom, Navigator, and Glucoday. RESEARCH DESIGN AND METHODS Accuracy data for the four CGMs were collected in two studies: Study 1 enrolled 14 adults with type 1 diabetes at the University of Virginia (UVA), Charlottesville, Virginia; study 2 enrolled 2...

BACKGROUND Continuous glucose monitors (CGMs) measure glucose in real time, making it possible to improve glycemic control. A promising technique involves glucose sensors implanted in subcutaneous tissue measuring glucose concentration in interstitial fluid. A major drawback of this technique is sensor bioinstability, which can lead to unpredictable drift and reproducibility. The bioinstability...