Germline mutations of the Liver Kinase b1 (LKB1/STK11) tumor suppressor gene have been linked to Peutz-Jeghers Syndrome (PJS), an autosomal-dominant, cancer-prone disorder in which patients develop neoplasms in several organs, including the oviduct, ovary, and cervix. We have conditionally deleted Lkb1 in Müllerian duct mesenchyme-derived cells of the female reproductive tract and observed expa...

Bilateral neurectomy of the pelvic nerve (BLPN) that carries uterine cervix-related sensory nerves induces dystocia, and administration of its vasoactive neuropeptides induces changes in the cervical microvasculature, resembling those that occur in the ripening cervix. This study was designed to test the hypothesis that (a) the cervix of pregnant rats expresses vascular endothelial growth facto...

As the critical gatekeeper for birth, prepartum remodeling of the cervix is associated with increased resident macrophages (Mφ), proinflammatory processes, and extracellular matrix degradation. This study tested the hypothesis that expression of genes unique to Mφs characterizes the prepartum from unremodeled nonpregnant cervix. Perfused cervix from prepartum day 21 postbreeding (D21) or nonpre...

Gastrin-releasing peptide (GRP) has been suggested as a novel regulatory peptide in the female reproductive tract but the presence of GRP and GRP mRNA in the non-neurogenic tissue of the cervix has not yet been clarified. In the present study, immunohistochemistry and in situ hybridization were used to reveal the distribution of GRP immunoreactivity and expression of GRP mRNA in the bovine cerv...

Alveolar soft part sarcoma (ASPS) is a tumor of unknown histogenesis, composed of large, epithelioid cells with eosinophilic cytoplasm, having an alveolar pattern. Primary ASPS of uterine cervix is very rare. In this report, we present a 21-aged-old female with primary ASPS in the uterine cervix and discuss the clinicopathological characteristics, immunophenotype, molecular genetic feature and ...

Abnormal looking cervix, or suspicious cervix, is a common clinical condition seen in gynecological practice. Colposcopic examination of the cervix allows differentiation between physiologic changes that occur in response to normal cyclic variations in hormone secretion and a variety of structural and pathological conditions. This article addresses some of these common clinical problems and pro...

Squamous cell carcinoma of endometrium is diagnosed as primary of endometrium if it meets the Fluhmann and Kay criteria [3,4] i.e. absence of concomitant endometrial adenocarcinoma, no continuity between endometrial tumour and stratied squamous epithelium of cervix, no primary carcinoma cervix and if cervix shows carcinoma insitu , there must be no connection between this and independent endom...

Carcinoma cervix was a leading cause of death in women in USA, fifty years ago. Terris and Oalmam and Ratkinhave repeatedly demonstrated a relationship between several parameters of sexual activity and carcinoma cervix. Epidemiological data suggested a sexually transmitted agent as risk factor based on, early age at first intercourse, multiple sexual partners and a male partner with multiple se...

a 22-year-old man presented with exertional dyspnea commencing one month prior to his admission. echocardiography revealed a non-homogenous mass, and the pathology examination of the pericardial biopsy was compatible with angiosarcoma.

Whether someone?s in a strictly monogamous relationship or exploring their sexuality with multiple partners, the most common cause of cervical cancer is human papillomavirus (HPV). This virus, which has many strains, has been linked to a number of cancers, including cervical cancer. The reason the risk of getting HPV increases along with the number of sexual partners a person has is as follows:...