Aberrant activation of the Wnt/β-catenin signaling axis is a prominent oncogenic mechanism in numerous cancers including cervical cancer. Wnt inhibitory factor-1 (WIF1) is a secreted protein that binds Wnt and antagonizes Wnt activity. While the WIF1 gene is characterized as a target for epigenetic silencing in some tumor types, WIF1 expression has not been examined in human cervical tissue and...

Cervical cancer is one of the major causes of women death worldwide. The aim of this study was to test the sensitivity and specificity of visual inspection with acetic acid (VIA) and visual inspection with lugol iodine (VILI) as a diagnostic test for cervical cancer in comparison with Pap smear in the North Cameroon region. 309 women aged between 20 to 62 years were recruited in this study. 307...

Introduction: Cervical lymph node metastases from papillary thyroid cancer were classified into three categories according to ultrasound: 1) Metastases not visible on ultrasound; 2) met initial criteria for the diagnosis; 3) typical diagnosis. Purpose: To develop ultrasound diagnosis of cervical cancer. Material and methods: We studied groups nodes in patients with The first group consisted 430...

PURPOSE Cervical cancer caused by the human papilloma virus (HPV) continues to be the cause of yearly death among women. However, it is a curable disease when diagnosed at an early stage. Recently, several researches have reported that heat shock protein (HSP) 60, a chaperone protein of molecular weight of 60 kDa, is involved in carcinogenesis and apoptosis. In order to evaluate the prognostic ...

We investigated the significance of high- mobility group box1 (HMGB1) and T-cell-mediated immunity and prognostic value in cervical cancer. HMGB1, forkhead/winged helix transcription factor p3 (Foxp3), IL-2, and IL-10 protein expression was analyzed in 100 cervical tissue samples including cervical cancer, cervical intraepithelial neoplasia (CIN), and healthy control samples using immunohistoch...

Bone marrow X-linked kinase (BMX, also known as Etk) has been reported to be involved in cell proliferation, differentiation, apoptosis, migration and invasion in several types of tumors, but its role in cervical carcinoma remains poorly understood. In this study, we showed that BMX expression exhibits a gradually increasing trend from normal cervical tissue to cervical cancer in situ and then ...

BACKGROUND Death-associated protein kinase1 (DAPK1) is an important tumor suppressor gene. DNA methylation can inactivate genes, which has often been observed in the carcinogenesis of cervical cancer. During the past several decades, many studies have explored the association between DAPK1 promoter methylation and cervical cancer. However, many studies were limited by the small samples size and...

experience with herpesvirus type 2 than with the presence or absence of cervical cancer. Thymidine kinase extracted from cervical cancer cells was found to migrate on polyacrylamide gel electrophoresis in a pattern similar to those of the enzymes induced in cells by herpesvirus types 1 or 2. The enzyme of the cancer tissue, however, did not appear to be antigenically related to the virus-induce...

cervical cancer is, globally known to be, one of the most common cancers among women especially indeveloping countries. more than 90% of cervical cancers are associated with high-risk humanpapillomaviruses (hpvs) particularly hpv types 16 and 18. two major strategies have been developed forprevention and treatment of cervical cancer and other hpv-associated malignancies; the first one is based ...