A 59-year-old man presented with refractory anemia, choreoathetosis in the left upper extremity, an unsteady gait and cognitive dysfunction. The laboratory findings showed a marked decrease in ceruloplasmin. Magnetic resonance images revealed iron deposition in the brain and visceral organs. Iron accumulation was also observed in hepatocytes. Genetic analyses of the ceruloplasmin gene revealed ...

Evidence is presented to indicate a generalized role for the terminal sialic acid residues of circulating glycoproteins. Upon injection into rats, all of the desialylated plasma proteins tested, with the exception of transfer& were promptly removed from the circulation and were recovered from the liver. The materials examined included orosomucoid, fetuin, ceruloplasmin, haptoglobin, arz-macrogl...

Previous immunochemical investigations of ceruloplasmin have been primarily concerned with the assay of this substance in human sera and its localization by the technique of immunoelectrophoresis. The proteins used in the preparation of antisera appear to have been impure or poorly defined. The ready availability of crystalline human ceruloplasmin (I, 2) prompted us to study its immunochemical ...

The major purpose of the present investigation was to study the effects of different concentrations of residual chlorine on serum iron related parameters in rats. Feeding male rats with water containing 80 ppm of residual chlorine daily for 5 days reduced serum levels of ceruloplasmin, copper, iron and hemoglobin by approximately 27%,23%,6% and 4%, respectively. Higher reductions in serum ...

We have analyzed the results of investigation alterations in indices pro-oxidant (conjugated diene and malondialdehyde) antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems guinea pigs’ lungs experimental allergic alveolitis dynamics EAA development under conditions immobilization stress. The was conducted on 62 female pigs weighing 180-220 g, divided into 4 groups: I – intact (n...

the relationship between different indices of the copper deficiency was studied in 136 slaughtered male cattle (< 2 years). copper status has been detected as marginally deficient in 57.4, 36.4, 34.6, and 28.2% of cattle based on the copper concentrations in plasma (5.5-14.5 μmol/l) and liver (19.7-189.1 mg/kgdm), plasma ceruloplasmin levels (85.4 - 178.2 mg/l) and erythrocyte superoxide dismut...

OBJECTIVE The ability to predict responses to chemotherapy for serous epithelial ovarian cancer (EOC) would be valuable since intrinsically chemoresistant EOC patients (persistent or recurrent disease within 6 months) gain little benefit from standard chemotherapy. The aim of this study was to screen and identify distinctive biomarkers in ascites of serous EOC associated with intrinsic chemores...