نتایج جستجو برای: certolizumab pegol
تعداد نتایج: 885 فیلتر نتایج به سال:
events were considered, reflecting the year 2015. All outcomes were discounted at 3.5% annually. Results: Regarding the AS subpopulation, the total treatment cost for IFX, ADA, CZP, ETA, GOL and CC was: € 67,736, € 38,914, € 38,721, € 38,290, € 35,338 and € 4,110; and the quality-adjusted life years (QALYs) were: 10.031, 9.882, 9.949, 9.933, 9.903 and 9.360, respectively. CZP dominated ADA and ...
BACKGROUND No equivalence analysis has yet been conducted on the effectiveness of biologics in rheumatoid arthritis. Equivalence testing has a specific scientific interest, but can also be useful for deciding whether acquisition tenders are feasible for the pharmacological agents being compared. METHODS Our search covered the literature up to August 2014. Our methodology was a combination of ...
A new anti-tumor necrosis factor alpha (TNF-α) inhibitor with a novel mechanism of action has entered phase 3 trials in rheumatoid arthritis (RA). Certolizumab pegol (Cimzia(®)) is a humanized Fab' antibody fragment against TNF-α with a polyethylene glycol tail that prevents complement-dependent and antibody-dependent cell-mediated cytotoxicity or apoptosis. Four randomized clinical trials have...
OBJECTIVE To assess the impact of certolizumab pegol (CZP), a novel PEGylated anti-tumor necrosis factor, in combination with methotrexate (MTX) on productivity outside and within the home, and on participation in family, social, and leisure activities in adult patients with rheumatoid arthritis (RA). METHODS The efficacy and safety of CZP (200 mg and 400 mg) plus MTX were assessed in 2 phase...
P-098 Serious Infections in Patients Treated with Certolizumab Pegol with or Without Corticosteroids
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