objective(s): protein kinase c (pkcα) is involved in modulating articular chondrocytes apoptosis induced by nitric oxide (no). hyaluronic acid (ha) inhibits nitric oxide-induced apoptosis of articular chondrocytes by protecting pkcα, but the mechanism remains unclear. the present study was performed to investigate the effects and mechanisms of pkcα regulate protective effect of hyaluronic acid....

objective(s) single injection of naloxone, a selective antagonist of morphine, prior to the drug conditioning testing was used to investigate on morphine dependence. materials and methods conditioning to morphine (2.5-10 mg/kg, s.c.) was established in adult male wistar rats (weighing 200-250 g) using an unbiased procedure. nitric oxide agents were microinjected into the central amygdala prior ...

objective(s) celecoxib acts through both cox-2-dependent and -independent pathways. according to the paradoxical effect of no on the inflammatory and nociceptive signal processing, the present study designed to evaluate the probable contribution of no in the analgesic and anti-inflammatory properties of celecoxib. materials and methods different intensities of inflammatory pain were induced by ...

introduction: response to morphine and role of nitric oxide (no) on expression of morphine response has been studied in vertebrates. but, little evidence is provided in the matter in earlier invertebrates. this investigation for the first time evaluated the effect of no on expression of morphine potency in paramecium caudatum. methods: animal after isolation from natural media and specific iden...

the combination of graphene (gr) and nickel oxide nanoparticles (nio nps) yields nanostructured electrochemical sensor formed a novel kind of structurally uniform and electrocatalytic activity material. in cyclic voltammetry (cv) studies, in the presence of ep, nio/gr composite modified electrode shows a significantly higher current response for ep oxidation. based on differential pulse voltamm...

introduction: since it is not possible to form an adequate micromechanical bond between resin cement and zirconia ceramics using common surface treatment techniques, laser pretreatment has been suggested for zirconia ceramic surfaces. the aim of this study was to evaluate the effect of carbon dioxide (co 2 ) laser treatment on shear bond strength (sbs) of resin cement to zirconia ceramic. metho...

a facile and simple method was proposed to control the size and shape of the mgo nano structures with high surface area in the presence of efficient and cheap templates like peg 200, peg 600, peg 4000 and sorbitol at low temperature within a little time. nano rods and nanoparticles have been achieved by applying these templates and altering other growth parameters. the products were characteriz...

introduction: pulpectomy is a conservative treatment plan for primary necrotic teeth and zinc oxide eugenol is still a good choice as root canal filling material but long term studies on poor prognosis molars are limited and almost contradictory. the purpose of this study is to evaluate the clinical and radiographical success rate of pulpectomy of necrotic primary molars using zoe as the root c...

in the past decade, magnetic nanomaterials have attracted much attention due to their physical properties and technological applications. in this work, α-fe2o3 nanoparticles were first synthesized via a simple co-precipitation method using iron chloride hexahydrate (fecl3.6h2o) as precursor and ammonia solution as precipitator. the samples were then characterized by high resolution transmission...