Ceramides are a family of sphingophospholipids synthesized in the endoplasmic reticulum, which mediate cell stress responses, including apoptosis, autophagy and senescence, Serine palmitoyltransferase generates 3-ketosphinganine, is reduced to dihydrosphingosine. N-Acylation allows formation dihydroceramides, subsequently form ceramides. Once synthesized, ceramides trafficked from ER Golgi boun...