Scorpion venom toxicity is of major concern due to its influence on human activities and public health. We investigated the in-vitro process of cell death caused by two Iranian scorpions Odontobuthus doriae and Bothutus salceyi venom on human cell lines. The aim of this study was to provide further information about triggering cell death and suggestion of methods for the elimination of unwanted...

The aim of this study was to evaluate and compare the cytotoxicity induced by two resin-based sealers, 2Seal and AH Plus, in two osteoblast-like cell lines, MG-63 and Saos-2. Using sterile discs of both sealers in complete media, 24- and 72-h extracts were prepared. The extracts were exchanged with Saos-2 or MG-63 cell culture media at 75% confluence, and after 24 h incubation, cell viability t...

Substituted phenylazo and phenylazoxy compounds were systematically prepared and their anti-androgenic activity was measured in terms of (1) the growth-inhibiting effect on an androgen-dependent cell line, SC-3, and (2) the binding affinity to nuclear androgen receptor. Generally, azo/azoxy compounds showed cell toxicity, and the growth-inhibiting effects on SC-3 cells correlated with the toxic...

background dox is a powerful chemotherapeutic agent used in the treatment of solid tumors and malignant hematological diseases. however, its cardiac toxicity limits the clinical usefulness of this drug. previous reports have shown corticosteroids induce a cytoprotective effect on cardiomyocytes. mouse transgenic embryonic stem cell-derived pure cardiomyocytes may be considered as a model for as...

objective(s): this study aimed to find out whether the chick cardiomyocyte micromass (mm) system could be employed to predict the teratogenecity of common environmental factors. different multivitamins and over the counter drugs were used in this study.   materials and methods: white leghorn 5-day-old embryo hearts were dissected and trypsinized to produce a cardiomyocyte cell suspension in dul...

background: bleomycin (blm) is an anti-cancer drug widely used in the treatment of cancer. blm causes several side effects related to dna and cellular damage. the aim of this study was investigated the effects of tea polyphenol epicatechin on anti-proliferative effects induced by bleomycin in human normal skin and human ovarian cancer cells.materials and methods: human ovarian cancer cell (skov...

The aim of the present study was to determine whether used orthodontic wires made of different materials cause toxicity and loss of viability on three-dimensional (3D) cell cultures. Three types of orthodontic wires, stainless steel, Nitinol, and TMA (n = 9) which had been used clinically in fixed appliances for a period of 1 month, were retrieved at random from five patients. Both upper and lo...

marine streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. the cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (dmehe) from marine derived actinomycete streptomyces sp. vitsjk8 was investigated against mouse embryonic fi...

general toxicity, antiproliferative, antibacterial and antioxidant activities of caulerpa peltata j.v.lamouroux (caulerpaceae) collected from oman sea were investigated. dried, ground alga was soxhlet-extracted with hexane, dichloromethane and methanol successively. the methanol extract was subjected to vacuum liquid chromatography (vlc) fractionation on silica gel using a step gradient of diff...