introduction: 90% of the tumors in the head and neck are squamous-cell carcinomas (hnscc), which have overall 5- year survival rate between 50% -60%. cd44 has been shown to be associated with the prognosis.  materials and methods: biopsy specimens of 51 patients with oral tongue scc were evaluated by immunohistochemistry (ihc) for the cd44 antibody.  results: there was no significant correlatio...

Background: Small cell lung cancer (SCLC) is a highly aggressive tumor. Objective: To evaluate the survival and time to progression of patients with SCLC admitted to a chest disease center in Istanbul, Turkey. Methods: Based on the reports of a pulmonary oncology clinic, data regarding performance status (PS), clinical stage of disease, treatment, time to progression and survival of 67 patients...

background little is known about the possible influence of demographic and histological risk factors on the survival of patients with esophageal and gastric cancer. objectives based on the available registry and follow-up information, this study compares 1-5 year survival rate of gastric and esophageal cancer. patients and methods through a concurrent (prospective) cohort study, all 366 patient...

an important aspect of microarray studies includes the prediction of patient survival based on their gene expression profile. to deal with the high dimensionality of this data, use of a dimension reduction procedure along with the survival prediction model is necessary. this study aimed to present a new method based on wavelet transform for survival relevant gene selection.the data included 204...

Background: Increasing the complexity in modern radiotherapy techniques have increased the delivery time lowering consequently the treatment efficacy. Through simulating the delivery time delay encountered in such techniques, its’ effect on two cancer cell lines and the compensating doses given to prevent such effect was investigated. Materials and Methods: F10B16 and 4T1 cancer cell line...

The a v b 3 integrin plays a fundamental role during the angiogenesis process by inhibiting endothelial cell apoptosis. However, the mechanism of inhibition is unknown. In this report, we show that integrinmediated cell survival involves regulation of nuclear factor-kappa B (NFk B) activity. Different extracellular matrix molecules were able to protect rat aortaderived endothelial cells from ap...

The loss of proliferative potential of a cell is often equated to cell kill, and many studies of the cellular effects of radiation (both ionising and non-ionising) utilise this definition of cell kill to define cell survival. To measure cell survival using this paradigm, a cell culture that has been exposed to a known dose of radiation is cultured and, at a predefined time post irradiation, the...