نتایج جستجو برای: cell line model

تعداد نتایج: 3813831  

Journal: :Journal of Pharmaceutical and Biomedical Analysis 2020

Journal: :modares journal of medical sciences: pathobiology 2012
roshanak najafi majid sadeghizadeh seyed javad mowla

objective: in an attempt to develop safer and more effective gene therapy approaches as a realistic treatment for various forms of cancer, researchers are increasingly using tumor-specific promoters (tsp) to drive the expression of the gene of interest and eradicate cancer cells. in this study, for the first time we introduce the oct-4 promoter as a cancer-specific promoter with a high efficacy...

Journal: :medical journal of islamic republic of iran 0
z soheili b goliaei from the laboratory of biophysics and molecular biology, institute 0f biochemistry and biophysics, university of tehran, tehran, i.r. iran.

transforming growth factor betas are multifunctional polypeptides in the cytokine superfamily. they have a growth inhibitory role on hemopoietic progenitor cells in semisolid colony assay as well as in long-term bone-marrow culture. tgf - β2 represses stromal cells, stem cell factor gene transcription, and decreases the stability of c-kit transcripts in hemopoietic cells. tgf-β also modulates g...

Introduction Green biosynthesis of the metallic nanoparticles is considered as one of the effective method for cancer treatment with minimum side effects. The objective of this study was the evaluation of cytotoxicity of zinc oxide (ZnO) nanoparticles synthesized with Ceratonia siliqua extract on the breast cancer cells and assessment of anti-angiogenesis properties of these nanoparticles in t...

Journal: :iranian journal of biotechnology 2007
roozbeh hushiarian mohammad roayaei hamid galehdari masoud reza seyfiabad shapouri

infectious bursal disease (ibd) is an economically important viral disease of chickens with worldwide distribution which suppresses the immune system of young chickens. vp2 is the major host-protective protein of infectious bursal disease virus (ibdv). the encoding region of vp2 protein was pcr amplified from a plasmid containing a cdna fragment of large genomic segment of ibdv, strain d78. thi...

Journal: :research in molecular medicine 0
ehsan zayerzadeh standard mohammad kazem koohi department of basic sciences, faculty of veterinary medicine, university of tehran, tehran, iran azadeh fardipour department of quality control, razi vaccine and serum research institute, karaj, iran

background: the organochlorine ddt has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. in the present investigation here, we studied the transcriptional effects of a synthetic organochlorine pesticide o,p’-ddt [1.1.1.-trichloro-2-(o-chlorophenyl)-2-p-chloriphenyl ethane] and its metabolite p,p'-dde (2-2-bis(4/chlorophenyl)-1-1-dic...

Journal: :iranian journal of pharmaceutical research 0
mona zamanian azodi proteomics research center mostafa rezaei-tavirani proteomics research center,shahid beheshti university of medical sciences sara rahmati-rad department of cell and molecular biology, faculty of science, university of tehran, tehran, iran majid rezaei-tavirani faculty of medicine, ilam university of medical sciences, ilam, iran

abstract ethanol has a vast consumption around the world. many researches confirmed some adverse effect of this component on human health. in addition, recent studies showed significant alteration in both cellular population, and protein profile of human foreskin fibroblast cell line (hfff2) in the specific dosage of ethanol. here, the role and interaction of some proteins (characterized by sig...

Journal: :basic and clinical cancer research 0
salar mokriani department of biology, faculty of basic science, urmia islamic azad university amir tokmachi department of biology, faculty of basic science, urmia islamic azad university majid nojavan department of pathobiology and quality control, urmia lake research institute, urmia university

background: chronic myeloid leukemia is a common cancer in human and chemical therapy is a routine method for treatment that has some side effects. so the goal of this study was the use of natural compound such as cell wall obtained from saccharomyces cerevisiae ( s. cerevisiae ) and saccharomyces boulardi ( s. boulardi ) and iron nanoparticles on the growth inhibition of k562 cell line. method...

Journal: :iranian journal of basic medical sciences 0
reza ebrahimzadeh-vesal department of medical genetics, faculty of medicine, tehran university of medical sciences, tehran, iran mohammad ali hokrgozar national cell bank of iran, pasteur institute of iran, tehran, iran karim nayernia institute of human genetics, north east england, stem cell institute, international center for life, newcastle university, newcastle, uk ladan teimoori-toolabi molecular medicine department, biotechnology research center, pasteur institute of iran mohammad miryounesi genomic research center, shahid beheshti university of medical sciences, tehran, iran seyedmehdi nourashrafeddin magee-womens research institute & foundation, university of pittsburgh medical sciences, pittsburgh, pa 15213, usa

objective(s):to culture thein vitro mouse embryonic stem cells (mescs) and to direct their  differentiation to germ-line cells; in present study we used a vector backbone containing the fusion construct stra8-egfp to select differentiated es cells that entered meiosis.  retinoic acid was used to differentiate embryonic stem cells to germ cells. materials and methods: a fragment of stra8 gene pr...

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