The nucleoside adenosine is present within cells and body fluids of all living organisms and its production, both intra- and extracellularly, is tightly coupled to energy consumption resulting in increased level of extracellular adenosine. The physiological effects of adenosine are mediated through four pharmacologically and biochemically distinct adenosine receptors (AR), i.e. A1, A2A, A2B and...

conclusions the pc-ns3 possesses the capacity to express ns3 in the mammalian cell line and demonstrated strong immunogenicity in a murine model. our primary results demonstrated that the immunogenic truncated region of ns3 could be used as a potential vaccine candidate against hepatitis c. results the pcdna3.1 plasmid harboring the coding sequence of ns3 (pc-ns3) was constructed and confirmed ...

Fault management is a crucial part of cellular network management systems. The status of the base stations is usually monitored by well-defined key performance indicators (KPIs). The approaches for cell degradation detection are based on either intra-cell or inter-cell analysis of the KPIs. In intra-cell analysis, KPI profiles are built based on their local history data whereas in inter-cell an...

This paper proposes a new integrative view of manufacturing cell formation and both inter-cell and intra-cell layout problems. Cells formation and their popular bi-directional linear layout are determined simultaneously through a Dynamic Programming algorithm (with the objective of minimizing the inter-cell flow cost under a cell size constraint). This Dynamic Programming algorithm is implement...

The intra-islet microvasculature is a critical interface between the blood and islet endocrine cells governing a number of cellular and pathophysiological processes associated with the pancreatic tissue. A growing body of evidence indicates a strong functional and physical interdependency of β-cells with endothelial cells (ECs), the building blocks of islet microvasculature. Intra-islet ECs, ac...

background: the water-soluble extract of ganoderma lucidum (reishi) has been used as an immunomodulator to stimulate spleen cells proliferation and cytokine expression. objective: to investigate the effect of ganoderma lucidum (g. lucidum) on cytokine production by mice peritoneal macrophages. methods: mice peritoneal macrophages were prepared by intra-peritoneal injection of 5 ml cold pbs. per...