نتایج جستجو برای: cdc42

تعداد نتایج: 3729  

Journal: :Journal of cell science 2008
Christian Böhmer Maik Böhmer Michael Bölker Björn Sandrock

In the dimorphic fungus Ustilago maydis the Rho-family GTP-binding protein Cdc42 and the Ste20-like kinase Don3 are both essential for triggering cell separation during cytokinesis. Since Don3 does not contain a Cdc42/Rac interaction and binding domain (CRIB), it is unclear how Cdc42 and Don3 cooperate in the regulation of cytokinesis. To analyse the regulatory network we generated an analogue-...

Journal: :Molecules 2018
Xing-Hua Xiao Lin-Chen Lv Jing Duan Ye-Meng Wu Shu-Jin He Zhen-Zhen Hu Li-Xia Xiong

Despite great improvements in the diagnosis and treatment of neoplasms, metastatic disease is still the leading cause of death in cancer patients, with mortality rates still rising. Given this background, new ways to treat cancer will be important for development of improved cancer control strategies. Cdc42 is a member of the Rho GTPase family and plays an important role in cell-to-cell adhesio...

2015
Anna M. Schulz Susanne Stutte Sebastian Hogl Nancy Luckashenak Diana Dudziak Céline Leroy Ignasi Forné Axel Imhof Stephan A. Müller Cord H. Brakebusch Stefan F. Lichtenthaler Thomas Brocker

Cell division cycle 42 (Cdc42) is a member of the Rho guanosine triphosphatase family and has pivotal functions in actin organization, cell migration, and proliferation. To further study the molecular mechanisms of dendritic cell (DC) regulation by Cdc42, we used Cdc42-deficient DCs. Cdc42 deficiency renders DCs phenotypically mature as they up-regulate the co-stimulatory molecule CD86 from int...

2016
Benjamin Rappaz Karen Lai Wing Sun James P. Correia Paul W. Wiseman Timothy E. Kennedy

Netrin-1 is an essential extracellular chemoattractant that signals through its receptor DCC to guide commissural axon extension in the embryonic spinal cord. DCC directs the organization of F-actin in growth cones by activating an intracellular protein complex that includes the Rho GTPase Cdc42, a critical regulator of cell polarity and directional migration. To address the spatial distributio...

2016
David A. F. Loebel Timothy F. Plageman Theresa L. Tang Vanessa J. Jones Maria Muccioli Patrick P. L. Tam

Early development of the gut endoderm and its subsequent remodeling for the formation of organ buds are accompanied by changes to epithelial cell shape and polarity. Members of the Rho-related family of small GTPases and their interacting proteins play multiple roles in regulating epithelial morphogenesis. In this study we examined the role of Cdc42 in foregut development and organ bud formatio...

Journal: :Blood 2010
Anastasia Sacharidou Wonshill Koh Amber N Stratman Anne M Mayo Kevin E Fisher George E Davis

Here, we define an endothelial cell (EC) lumen signaling complex involving Cdc42, Par6b, Par3, junction adhesion molecule (Jam)-B and Jam-C, membrane type 1-matrix metalloproteinase (MT1-MMP), and integrin alpha(2)beta(1), which coassociate to control human EC tubulogenesis in 3D collagen matrices. Blockade of both Jam-B and Jam-C using antibodies, siRNA, or dominant-negative mutants completely...

Journal: :Molecular biology of the cell 2005
Kazuhiro Aoki Takeshi Nakamura Keiko Fujikawa Michiyuki Matsuda

Neurite outgrowth is an important process in the formation of neuronal networks. Rac1 and Cdc42, members of the Rho-family GTPases, positively regulate neurite extension through reorganization of the actin cytoskeleton. Here, we examine the dynamic linkage between Rac1/Cdc42 and phosphatidylinositol 3-kinase (PI3-kinase) during nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. ...

Journal: :The Journal of Cell Biology 2004
Roland Wedlich-Soldner Stephanie C. Wai Thomas Schmidt Rong Li

Yeast cells can initiate bud formation at the G1/S transition in a cue-independent manner. Here, we investigate the dynamic nature of the polar cap and the regulation of the GTPase Cdc42 in the establishment of cell polarity. Using analysis of fluorescence recovery after photobleaching, we found that Cdc42 exchanged rapidly between the polar caps and cytosol and that this rapid exchange require...

2016
Sui-Chih Tien Hsiao-Hui Lee Ya-Chi Yang Miao-Hsia Lin Yu-Ju Chen Zee-Fen Chang

Regulation of Shp2, a tyrosine phosphatase, critically influences the development of various diseases. Its role in epithelial lumenogenesis is not clear. Here we show that oncogenic Shp2 dephosphorylates Tuba to decrease Cdc42 activation, leading to the abnormal multi-lumen formation of epithelial cells. HDAC6 suppression reverses oncogenic Shp2-induced multiple apical domains and spindle mis-o...

Journal: :Cell 1996
Margaret M Chou John Blenis

The 70 kDa ribosomol S6 kinase (pp70S6k) plays an important role in the progression of cells through G1 phase of the cell cycle. However, little is known of the signaling molecules that mediate its activation. We demonstrate that Rho family G proteins regulate pp70S6k activity in vivo. Activated alleles of Cdc42 and Rac1, but not RhoA, stimulate pp70S6k activity in multiple cell types. Activati...

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