The present study was aimed to evaluate the possibility of using anti-human monoclonal antibody CD3 as pan T-cell marker in guinea pigs’ trachea and lung early late manifestations allergic inflammatory process.
 Materials methods.We have studied distribution quantitative changes CD3-positive lymphocytes pigs histological, immunohistochemical, statistical methods conditions experimental Res...

PURPOSE The purpose of this study was to investigate the clinical role of immunological recovery together with selected biological parameters on long-term survival in a series of ovarian cancer administered high-dose chemotherapy with peripheral blood stem cell and growth factor support. EXPERIMENTAL DESIGN Thirty-eight patients with stages IIIB-IV epithelial ovarian cancer were studied. Lymp...

objective: to determine the diagnostic value of blood cells surface markers in patients with acute appendicitis. methods: in this cross-sectional study, 71 patients who underwent appendectomy following a diagnosis of appendicitis were recruited during a one-year period. the patients were divided into two groups: patients with histopathologically confirmed acute appendicitis and subjects with no...

Induction of T-cell activation requires multiple signals provided by cell surface receptor interactions and/or cytokines. T-cell stimulation via the T-cell receptor/CD3 complex provides an important initial activation event which, when combined with the proper costimulatory signals, re sults in an activated effector T cell. In this report, we have investigated the effectiveness of epithelial gl...

In this study the effects of CD45 engagement on CD3-TCR-driven stimulation of CD1+ human immature thymocytes have been analyzed. Simultaneous cross-linking of CD45 and CD3 antigens on highly purified CD1+ thymocytes reduced the number of cells undergoing apoptosis after 16 h of in vitro culture. This cell population might represent immature thymocytes committed in vivo to die by programmed cell...

The function of T-cell receptor (TCR) gene modified T cells is dependent on efficient surface expression of the introduced TCR α/β heterodimer. We tested whether endogenous CD3 chains are rate-limiting for TCR expression and antigen-specific T-cell function. We show that co-transfer of CD3 and TCR genes into primary murine T cells enhanced TCR expression and antigen-specific T-cell function in ...

Fresh peripheral blood mononuclear cells exposed to alloantigen for 3-8 d in the presence of anti-CD3 antibodies showed no response after restimulation with cells from the original donor but remained capable of responding to third-party donors. Antigen-specific nonresponsiveness was induced by both nonmitogenic and mitogenic anti-CD3 antibodies but not by antibodies against CD2, CD4, CD5, CD8, ...

Abstract Respiratory syncytial virus (RSV) is an RNA that belongs to the Pneumovirus genus of Paramyxoviridae family. The aim this study was evaluate expressions inducible nitric oxide synthetase (iNOS), CD3 (pan T cells), and CD8 (cytotoxic cells) in lamb lungs naturally infected with RSV using immunohistochemistry (IHC). For purpose, 100 pneumonic 10 control lung tissue samples were taken fro...

Currently approved therapies for multiple sclerosis and other chronic inflammatory diseases dampen proinflammatory immune responses, but lack selectivity. For some of these medications, the consequent immune suppression may predispose patients to serious opportunistic infections. An ideal therapy might target only those cells that are autoreactive, while maintaining the ability to discriminate ...