MicroRNAs (miRNAs) have been shown to be important for the pathogenesis of Crohn's disease (CD). Exclusive enteral nutrition (EEN) is an effective therapy for inducing remission in CD. We aimed to investigate the alteration of miRNAs expression profile in the terminal ileal mucosa of CD patients before and after EEN. Twenty-five patients and ten healthy individuals were included. MiRNAs express...

Downlo rgy history has been consistently inversely associated with glioma risk. Two serologic markers, soluble (sCD23) and soluble CD14 (sCD14), are part of the innate and adaptive humoral immune systems and late allergic responses in opposite directions, with sCD23 enhancing and sCD14 blunting inflammatory ses. We measured sCD23 and sCD14 in serum from blood that was drawn at a single time poi...

The increased incidence of idiopathic cardiovascular disorders in the modern society has highlighted on the putative role of metals deposition in human body with the development of chronic disorders in urban area. In this study was carried out to assess the influence of smoking on cadmium deposition in acute (blood) and chronic (hair) storage sites. 200 healthy Saudi citizens in Hail district, ...

Reduced graphene oxide-supported nanoscale zero-valent iron (nZVI/rGO) composites were synthesized in the present study by chemical deposition method and were then characterized by various methods, such as Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). The nZVI/rGO composites prepared were utilized for Cd(II) removal from aqueous solutions in batch mo...

Various indices have been used to assess Crohn's disease (CD). However, the question of whether the Crohn's Disease Activity Index (CDAI) is associated with coagulation function has not been fully confirmed. In this study, we examined the association between CDAI and the coagulation and fibrinolysis parameters. In a retrospective and observational cohort study, the CDAI of 108 patients from two...

A novel method to efficiently generate unmarked in-frame gene deletions in Rhodococcus equi was developed, exploiting the cytotoxic effect of 5-fluorocytosine (5-FC) by the action of cytosine deaminase (CD) and uracil phosphoribosyltransferase (UPRT) enzymes. The opportunistic, intracellular pathogen R. equi is resistant to high concentrations of 5-FC. Introduction of Escherichia coli genes enc...

Vacuum UV circular dichroism (CD) spectra were measured down to 174 nm for five homopolymers, five duplexes, and four triplexes containing adenine, uracil, and thymine. Near 190 nm, the CD bands of poly[d(A)] and poly[r(A)] were larger than the CD bands of the polypyrimidines, poly[d(T)], poly[d(U)], and poly[r(U)]. Little change was observed in the 190 nm region upon formation of the duplexes ...

The impacts of information and communication technologies (ICT) on the environment have been a rich area for research in recent years. ICT has substantially affected commerce, enabling new methods for connecting producers and consumers (i.e., e-commerce) and creating new electronic products. A prime example is the continuing rise of digital music delivery, which has obvious potential for reduci...

Oleuropein (OLE) is a major constituent of the olive leaf and green olives (Olea europaea). It has antioxidant and therapeutic properties and is valued as a medicinal component. The molecule is a complex phenolic compound constituted by a heterosidic ester of the elenolic acid and dihydroxy ethanol. This work concerns the determination of the inclusion complex constants between OLE and cyclodex...

The objectives of this study were (1) to determine cadmium (Cd) accumulation in the midgut gland of a land snail Helix pomatia L. inhabiting residential areas of the 14 largest cities in Poland, and (2) to examine whether the accumulated Cd exerted any toxic effects. The average accumulation of Cd in the midgut gland of snails, weighing 16-18 g, ranged from 7.00 to 87.3 µg/g dry weight (0.06-0....