نتایج جستجو برای: ccl22

تعداد نتایج: 1448  

Journal: :Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2018
Yi-Ching Lin Ming-Yii Huang Min-Sheng Lee Chong-Chao Hsieh Hsuan-Fu Kuo Chang-Hung Kuo Chih-Hsing Hung

BACKGROUND/PURPOSE Asthma is a chronic airway inflammatory disease mediated by T-helper (Th)2 cells. Montelukast (trade name Singulair) is a cysteinyl leukotriene receptor antagonist used for asthma treatment. Mirroring Th1-Th2 polarization, two distinct states of macrophages have been recognized: the classically activated (M1) macrophages and the alternatively activated (M2) macrophages. M2 po...

Journal: :Journal of immunology 2008
Sun Ying Brian O'Connor Jonathan Ratoff Qiu Meng Cailong Fang David Cousins Guizhen Zhang Shuyan Gu Zhongli Gao Betty Shamji Matthew J Edwards Tak H Lee Chris J Corrigan

Asthma and chronic obstructive pulmonary disease (COPD) are associated with Th2 and Th1 differentiated T cells. The cytokine thymic stromal lymphopoietin (TSLP) promotes differentiation of Th2 T cells and secretion of chemokines which preferentially attract them. We hypothesized that there is distinct airways expression of TSLP and chemokines which preferentially attract Th1- and Th2-type T cel...

Journal: :Journal of immunology 2007
Steven R Beaty C Edward Rose Sun-Sang J Sung

Lung CD11c(high) dendritic cells (DC) are comprised of two major phenotypically distinct populations, the CD11b(high) DC and the integrin alpha(E)beta(7)(+) DC (CD103(+) DC). To examine whether they are functionally distinguishable, global microarray studies and real-time PCR analysis were performed. Significant differences between the two major CD11c(high) DC types in chemokine mRNA expression...

2014
JAMIE L. McCLELLAN JENNIFER L. STEINER STANI D. DAY REILLY T. ENOS MARK J. DAVIS UDAI P. SINGH E. ANGELA MURPHY

Many observational epidemiologic studies suggest an association between exercise and colon cancer risk. The mechanisms contributing to a preventative effect of exercise on colon cancer are complex and multifaceted. Altered immune system function is one possible mechanism that has been largely unexplored. Therefore, the purpose of this study was to examine the effects of exercise on markers asso...

2016
Mieke Gouwy Pieter Ruytinx Egle Radice Federico Claudi Katrien Van Raemdonck Raffaella Bonecchi Massimo Locati Sofie Struyf

Upon inflammation, circulating monocytes leave the bloodstream and migrate into the tissues, where they differentiate after exposure to various growth factors, cytokines or infectious agents. The best defined macrophage polarization types are M1 and M2. However, the platelet-derived CXC chemokine CXCL4 induces the polarization of macrophages into a unique phenotype. In this study, we compared t...

2015
Smanla Tundup Leena Srivastava Thomas Norberg Wendy Watford Donald Harn Abhay R Satoskar

The milk pentasaccharide LNFPIII has therapeutic action for metabolic and autoimmune diseases and prolongs transplant survival in mice when presented as a neoglycoconjugate. Within LNFPIII is the Lewisx trisaccharide, expressed by many helminth parasites. In humans, LNFPIII is found in human milk and also known as stage-specific embryonic antigen-1. LNFPIII-NGC drives alternative activation of ...

Journal: :Journal of reproductive immunology 2014
Martina Sandberg Abelius Uta Enke Frauke Varosi Heike Hoyer Ekkehard Schleussner Maria C Jenmalm Udo R Markert

The immunological milieu in the placenta may be crucial for priming the developing foetal immune system. Early imbalances may promote the establishment of immune-mediated diseases in later life, including allergies. The initial exposure to allergens seems to occur in utero, but little is known about allergen-induced placental cytokine and chemokine release. The release of several cytokines and ...

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