George K. Tofaris,1 Pablo Garcia Reitböck,1 Trevor Humby,2 Sarah L. Lambourne,2 Mark O’Connell,1 Bernardino Ghetti,3 Helen Gossage,1 Piers C. Emson,2 Lawrence S. Wilkinson,2 Michel Goedert,4 and Maria Grazia Spillantini1 1Centre for Brain Repair and Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 2PY, United Kingdom, 2The Babraham Institute, Cambridge CB2 4AT, Unite...

David W. Hampton,1,3* Daniel J. Webber,1,2,3* Bilada Bilican,1,2,3 Michel Goedert,4 Maria Grazia Spillantini,3 and Siddharthan Chandran1,2,3 1Euan MacDonald Centre for Motor Neurone Disease Research, Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom, 2Anne McLaren Laboratory for Regenerative Medicine, Medical Research Council Centre for Stem Cell Biol...

There is now a large body of data indicating that the cannabinoid receptor type 2 (CB2) is linked to a variety of immune events. This functional relevance appears to be most salient in the course of inflammation, a process during which there is an increased number of receptors that are available for activation. Studies aimed at elucidating signal transduction events resulting from CB2 interacti...

Cannabinoid receptors (CB1 and CB2) and their endogenous ligands (endocannabinoids) have recently emerged as novel mediators of liver diseases. Endogenous activation of CB1 receptors promotes nonalcoholic fatty liver disease (NAFLD) and progression of liver fibrosis associated with chronic liver injury; in addition, CB1 receptors contribute to the pathogenesis of portal hypertension and cirrhot...

Kanabidiol, CB1 ve CB2 reseptörlerine düşük bağlanma eğilimine (afiniteye) sahip psikoaktif özellikleri olmayan bir kanabinoiddir. Ayrıca G proteinine bağlı reseptörler, serotonin reseptörleri opioid ile de aktivite göstermektedir. Bu nedenle kanabidiol uzun zamandır anksiyete, depresyon, refrakter epilepsi gibi nöronal hastalıkların, Parkinson, Alzheimer hastalığı, amyotrofik lateral skleroz s...

In light of the adverse side-effects of opioids, cannabinoid receptor agonists may provide an effective alternative for the treatment of cancer pain. This study examined the potency and efficacy of synthetic CB1 and CB2 receptor agonists in a murine model of tumor pain. Intraplantar injection of the CB1 receptor agonist arachidonylcyclopropylamide (ED(50) of 18.4 μg) reduced tumor-related mecha...

Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian tissues. Although selective antagonists are available for each of the subtypes, most of the available cannabinoid agonists bind to both CB1 and CB2 with similar affinities. We have synthesized two analogs of N-arachidonylethanolamine (AEA), arachidonylcyclopropylamide (ACPA) and arachidonyl-2-chloroethylamide (ACE...

Paraquat, a widely used herbicide, is well known to exhibit oxidative stress and lung injury. In the present study, we investigated the possible underlying mechanisms of cannabinoid receptor-2 (CB2) activation to ameliorate the proinflammatory activity induced by PQ in rats. JWH133, a CB2 agonist, was administered by intraperitoneal injection 1 h prior to PQ exposure. After PQ exposure for 4, 8...

We had previously shown that both locally produced endocannabinoids and exocannabinoids, via cannabinoid receptor-1 (CB1), are powerful inhibitors of human hair growth. To further investigate the role of the cannabinoid system in pilosebaceous unit biology, we have explored in the current study whether and how endocannabinoids have an impact on human sebaceous gland biology, using human SZ95 se...