Hydrostatic pressure induces structural changes in proteins, including denaturation, the mechanism of which has been attributed to water penetration into the protein interior. In this study, structures of 3-isopropylmalate dehydrogenase (IPMDH) from Shewanella oneidensis MR-1 were determined at about 2 Å resolution under pressures ranging from 0.1 to 650 MPa using a diamond anvil cell (DAC). Al...

Complexity of the geometry and structure of the heart hampers easy modeling of cardiac mechanics. The modeling can however be simplified considerably when using the hypothesis that in the normal heart myofiber structure and geometry adapt, until load is evenly distributed. A simple and realistic relationship is found between the hemodynamic variables cavity pressure and volume, and myofiber loa...

We report on experimental measurement of air damping effects in high frequency nanomembrane resonators made of atomically thin molybdenum disulfide (MoS2) drumhead structures. Circular MoS2 nanomembranes with thickness of monolayer, few-layer, and multi-layer up to 70 nm ( 100 layers) exhibit intriguing pressure dependence of resonance characteristics. In completely covered drumheads, where the...

We theoretically study the model of a hybrid cavity–Bose–Einstein condensates (BEC) system that consists two-level impurity atom coupled to cavity–BEC with radiation pressure coupling, where is weakly driven by monochromatic laser field. The steady-states behavior entire researched in framework impurity–cavity coupling dispersive limit. find multiple types photon steady-state antibunching effec...

We report on experimental observation of radiation-pressure induced effects in a high-power optical cavity. These effects play an important role in next generation gravitational wave (GW) detectors, as well as in quantum non-demolition (QND) interferometers. We measure the properties of an optical spring, created by coupling of an intense laser field to the pendulum mode of a suspended mirror; ...

A comprehensive study of the problem of modelling vaporous cavitation in transmission lines is presented. The two-phase homogeneous equilibrium vaporous cavitation model which has been developed is compared with the conventional column separation model. The latter predicts unrealistically high pressure spikes because of a conflict arising from the prediction of negative cavity sizes if the pres...

Sound pressure level in-situ measurements are sensitive to standing-wave pressure minima and have the potential to result in over-amplification with risk to residual hearing in hearing-aid fittings. Forward pressure level (FPL) quantifies the pressure traveling toward the tympanic membrane and may be a potential solution as it is insensitive to ear-canal pressure minima. Derivation of FPL is de...

A 50-year-old man was admitted for evaluation of syncope. Clinically, he had an irregular pulse and an ejection systolic murmur loudest at the left sternal border. Transthoracic echocardiography revealed hypertrophic cardiomyopathy (HCM) with midventricular obstruction and apical aneurysm with maximum pressure gradient greater than 74 mm Hg. Coronary angiogram showed normal coronary arteries. L...

abstract background: we aimed to evaluate an approach to induced abortions during early pregnancies that controls the suction pressure and restricts the duration of the procedure. methods: three hundred patients programmed for induced early pregnancy abortions, hospitalized in the shandong provincial maternity & child care hospital from october 2013 to october 2015, were enrolled. patients were...

A Hohlraum-like configuration is proposed for realizing a simple compact source for neutrons. A laser pulse enters a tiny thin-shelled hollow-sphere target through a small opening and is self-consistently trapped in the cavity. The electrons in the inner shell-wall region are expelled by the light pressure. The resulting space-charge field compresses the local ions into a thin layer that become...