9 February Dementia – from Local to Global Plenary Lecture 10 February The Neuropsychiatry of the Dementias Catatonia Guest Lecture 11 February Child Neuro-Psychiatric disorders in adult life Neuropsychiatry and Literature Keynote Speaker INSTITUTE OF CHILD HEALTH, central London

BACKGROUND Phelan-Mc Dermid syndrome is a contiguous disorder resulting from 22q13.3 deletion implicating the SHANK3 gene. The typical phenotype includes neonatal hypotonia, moderate to severe intellectual disability, absent or delayed speech, minor dysmorphic features and autism or autistic-like behaviour. Recently, point mutations or micro-deletions of the SHANK3 gene have been identified, ac...

Kahlbaum characterised catatonia as a specific disturbance in motor functioning which represents a phase in a progressive illness that includes stages of mania, depression and psychosis that typically ends in dementia. Kraepelin incorporated features of catatonia into his concept of dementia praecox and Bleuler, under the heading of catatonic symptoms, gave the fullest account of schizophrenic ...

Catatonia has been described in children with intellectual disabilities (IDs). These are the first three published cases of catatonia in adults older than 50 years of age with IDs. They were followed using the KANNER scale and, in one case, creatinine phosphokinase (CPK) monitoring. Case 1 is a 67-year-old Caucasian who probably had been having intermittent episodes of undiagnosed catatonia wit...

Multiple sclerosis can create a variety of somatic, cognitive, and behavioral symptoms. Here we report a patient with early psychiatric symptoms including depression, dementia, and catatonia, who was eventually diagnosed as having primary progressive multiple sclerosis.

A substantial amount of evidence has proposed an important role for Cyclooxygenase-2 (COX-2) enzyme in brain diseases and affiliate disorders. The purpose of this research was studying the effects of COX-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and Parkinson's disease (PD). In this study, the effect of acute and Sub-chronic oral administration ...

BACKGROUND Periodic catatonia is a familial subtype of schizophrenia characterized by hyperkinetic and akinetic episodes, followed by a catatonic residual syndrome. The phenotype has been evaluated in two independent genome-wide linkage scans with evidence for a major locus on chromosome 15q15, and a second independent locus on chromosome 22qtel. METHODS In the positional and brain-expressed ...