Hip hemiarthroplasty is a common treatment for femoral neck fracture. However, the acetabular cartilage may degenerate after hemiarthroplasty leading to postoperative failure and the need for revision surgery. The clearance between the acetabular cartilage and head of the prosthesis is one of the potential reasons for this failure. In this study, the influence of joint clearance on the biomecha...

Fracture is a break in the continuity of bone, joint epiphyseal cartilage, which total or partial. Currently musculoskeletal disease has become problem that often found health care centers around world. Overall incidence fractures was 11.3 1,000 per year, males 11.67 1000 whereas 10.65 women year. The classic symptom history trauma fracture, pain and swelling broken bones, deformity, dysfunctio...

INTRODUCTION The molecular mechanisms underlying cartilage destruction in osteoarthritis are poorly understood. Proteolysis is a key feature in the turnover and degradation of cartilage extracellular matrix where the focus of research has been on the metzincin family of metalloproteinases. However, there is strong evidence to indicate important roles for other catalytic classes of proteases, wi...

BACKGROUND Osteoarthritis (OA) is one of the most common joint diseases in elderly people, however, the underlying mechanism of OA pathogenesis is not completely clear. Periostin, the extracellular protein, has been shown by cDNA array analysis to be highly expressed in OA, but its function is not fully understood. The purpose of this study was to examine the expression and function of periosti...

Anterior cruciate ligament injuries in skeletally immature patients usually involve tibial bony avulsion fractures rather than the midsubstance tears usually observed in adults. Several surgical techniques have been reported to provide stable fixation and avoid physeal injury in this pediatric population. The authors propose a novel, reproducible surgical technique using bioabsorbable anchors t...

BACKGROUND The role of the location and severity of the initial cartilage lesions associated with an ankle fracture in the development of posttraumatic osteoarthritis has not been established, to our knowledge. METHODS We performed a long-term follow-up study of a consecutive, prospectively included cohort of 288 ankle fractures that were treated operatively between June 1993 and November 199...

Introduction Astronauts involved in space exploration, including interplanetary travel, the construction of orbiting stations, and the maintenance of planet-based facilities, will be exposed to the risk of serious injury including the risk of fracture. This risk flows from the combined effects of a deleterious impact of microgravity on bone mass (decreased bone formation and increased resorptio...

OBJECTIVE To determine the risk of injury in youth football games. SUBJECTS AND METHODS Nine hundred fifteen players aged 9 to 13 years on 42 teams participated, including 10 teams in each grade from grades 4 through 6 and 6 teams each in grades 7 and 8. The study was conducted in the fall of 1997. Injury incidence, prevalence, and severity were calculated for each grade level and player posi...

*Furman, BD; *Strand, J; *Hembree, WC; *Guilak, F; +*Olson, SA +*Duke University Medical Center, Division of Orthopaedic Surgery, Durham, NC [email protected] INTRODUCTION: Post-traumatic arthritis is one of the most frequent causes of disability following trauma involving weight-bearing joints. It is estimated that 10% of the 21 million Americans suffering from osteoarthritis are post-traumati...

BACKGROUND AND PURPOSE Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity, which is the rate-limiting enzyme in the synthesis of prostaglandins. Previous studies have indicated that NSAID therapy, and in particular NSAIDs that specifically target the inflammatory cyclooxygenase (COX-2), impair bone healing. We compared the effects of ibuprofen and rofecoxib on ...