L‐carnitine (free carnitine) transports cytosolic long‐chain fatty acids as acylcarnitines across the inner mitochondrial membrane for β‐oxidation and subsequent ATP production in the mitochondria. The endogenous carnitine pool comprises free L-carnitine as well as short-, mediumand long-chain fatty acid esters (acyl-carnitines) and depends on absorption of L-carnitine from dietary sources, end...

Mutations in the gene that encodes the principal l-carnitine transporter, OCTN2, can lead to a reduced intracellular l-carnitine pool and the disease Primary Carnitine Deficiency. l-Carnitine supplementation is used therapeutically to increase intracellular l-carnitine. As AMPK and insulin regulate fat metabolism and substrate uptake, we hypothesized that AMPK-activating compounds and insulin w...

In addition to hemorrhagic cystitis, Fanconi Syndrome is a serious clinical side effect during ifosfamide (IFO) therapy. Fanconi syndrome is a generalized dysfunction of the proximal tubule which is characterized by excessive urinary excretion of glucose, phosphate, bicarbonate, amino acids and other solutes excreted by this segment of the nephron including L-carnitine. Carnitine is essential c...

Twelve sows were used to examine the effects of feeding L-carnitine from artificial insemination to mid-gestation on maternal circulating IGF-I and carnitine concentrations and fetal growth. Supplementing L-carnitine did not influence the serum concentration of IGF-I. However, sows that were fed carnitine had increased circulating plasma free carnitine. Litters from sows fed L-carnitine were he...

The in vivo effects of dexamethasone administration on liver and extrahepatic tissue carnitine concentrations were assessed in 48-h-starved rats. In heart and kidney, but not in liver, dexamethasone significantly increased total carnitine concentration. Acute (2.5 h) treatment with 2-tetradecylglycidate (TDG), a specific inhibitor of carnitine palmitoyl transferase 1, not only increased total h...

background: l-carnitine may prevent the incidence of aki by its antioxidant effects and improving circulation in ischemic conditions. the goal of this trial was to evaluate the impact of l-carnitine on contrast-induced nephropathy in patients undergoing elective pci. methods: totally, the patients were randomly allocated to 2 groups. the treatment group received 1 g of l-carnitine orally 3 time...

Background: Ventricular septal defect (VSD) and Atrial (ASD) are the most common congenital heart disease (CHD). This study aimed to improve of health status, quality life, morbidity mortality pediatrics patient with ASDs. Methods: was a cohort carried out at Pediatric Cardiology Unit Zagazig University hospitals during period from October 2019 2020 Included 30 children up 2 years age were foll...

Previous studies from this laboratory and by Wittels and Bressler have suggested that myocardial carnitine depletion and an accompanying decrease in fatty acid oxidation may contribute to the myocardial disease associated with diphtheria. In addition, administration of carnitine was found to prolong survival of diphtheritic guinea pigs and improve ventricular function in diphtheritic dogs. The ...

Carnitine and its derivatives have recently been shown to protect cardiac metabolism and function in ischemic heart disease and other clinical conditions of myocardial ischemia. Potential mechanisms of this effect include an increase in glucose metabolism, a reduction of toxic effects of long-chain acyl-CoA and acyl-carnitine in myocytes, an increase in coronary blood flow and anti-arrhythmic e...

A wide range of morphological and biochemical changes occur in the central nervous system with increasing age. L-carnitine, a naturally occurring compound, plays a vital role in fatty acid transport across the mitochondrial membrane. L-carnitine (300 mg/kg body wt/day) was administered intraperitoneally to young and old male Wistar rats for 7, 14, and 21 days. Carnitine, dopamine, epinephrine, ...