The effects of long-term treatment with a novel angiotensin I converting enzyme (ACE) inhibitor, trandolapril, on ACE activity and cardiac function in rats with chronic heart failure (CHF) were examined and compared with those of captopril and enalapril. Left coronary artery ligation of rats resulted in decreases in mean arterial pressure, left ventricular systolic pressure, dP/dt, cardiac outp...

Cardiologists and patients contemplate the risk of proposed operations. Surgeons typically report outcomes on operations performed. Emergency intraoperative crossover from off- to on-pump coronary artery bypass grafting occurs uncommonly but has substantial rates of mortality and morbidity. Much of the reported perioperative benefit of off- compared with on-pump coronary artery bypass grafting ...