and tricuspid regurgitation, indicative of increased right ventricular stroke volume. A pulmonary-to-systemic flow ratio of 2:1, due to an ostium secundum type-atrial septal defect, could be accurately diagnosed by Doppler echocardiography. Symptoms disappeared sponta-nously within a few minutes after hospital admission without therapy. Laboratory examination revealed elevated serum concentrati...

Editorial Why inotropes continue to disappoint in heart failure Despite their low therapeutic index, cardiac glycosides have been used for centuries for the treatment of heart failure. In the past two decades pharmaceutical companies have developed several new orally active drugs, which like the glycosides have positive inotropic activity in vitro. It was hoped that they would replace the glyco...

The presence or absence of cyanogenic glycosides was determined for individuals from nine populations of Sambucus canadensis L. (elderberry) of east-central Illinois. In most of the populations tested, all or most of the individuals did not produce these compounds, in one, all were cyanogenic, whereas in another population this trait was highly variable. Addition of the enzyme emulsin to negati...

Four antibacterial compounds were isolated from leaves of guava (Psidium guajava L.), and the structures of these compounds were established on the basis of chemical and spectroscopic evidence. Two new flavonoid glycosides, morin-3-O-alpha-L-lyxopyranoside and morin-3-O-alpha-L-arabopyranoside, and two known flavonoids, guaijavarin and quercetin, were identified. The minimum inhibition concentr...

From the leaves and branches of Markhamia stipulata, five verbascoside derivatives (markhamiosides A-E), and one hydroquinone derivative (markhamioside F) were isolated together with 13 known compounds. Their structural elucidation was based on analyses of chemical and spectroscopic data.

Natural products have long been regarded as excellent sources for drug discovery given their structure diversity and wide variety of biological activities. Phenylethanoid glycosides are naturally occurring compounds of plant origin and are structurally characterized with a hydroxyphenylethyl moiety to which a glucopyranose is linked through a glycosidic bond. To date several hundred compounds o...

to its glycoside (arachidoside) content. On the basis of in creased excretion of phenols in the group of rats fed arachi doside, and of an increased iodine content in the phenolic fraction of the urine as compared with the control, it was sug gested that this glycoside acted as an antithyroid compound by forming molecular compounds with elemental iodine in the gland. Confirmatory evidence for t...

Two flavan-3-ol glycosides together with seven flavan-3-ols were isolated from stems of the mangrove plant, Rhizophora stylosa. Their structures were established as glabraoside A (7) and glabraoside B (8) by spectroscopic and chemical methods. The antioxidative activity of these isolated compounds evaluated by the diphenylpicrylhydrazyl (DPPH) radical scavenging reaction was higher than that of...

Two new phloroglucinol glycosides, lysidisides C (1) and D (2), together with two new resveratrol glycosides, lysidisides E (3) and F (4), were isolated from the n-BuOH extract of the roots of Lysidice rhodostegia. The structures were elucidated on the basis of spectroscopic and chemical evidence. The antioxidant activity of the isolates was also investigated

Besides caffeic acid three pyrones have been isolated from aquous bark extracts from Acosmium panamense and their structures were determined using spectroscopical methods. Besides the already described desmethylyangonine its O4'-mono as well as the di(1-6)glucoside are found the first time.