Caspase-associated recruitment domains (CARD) are protein-protein interaction modules found extensively in proteins that play important roles in apoptosis, NFkappaB activation, and cytokine regulation. In this study we identified a novel human protein, CARD-8, which contains a C-terminal CARD domain with high similarity to the CARD domain of caspase-1/ICE. We demonstrate that CARD-8 interacts p...

The advent of New Zealand’s world-leading Digital Strategy underpins the increasing importance of ICTs in community settings. It also marks a significant change in government policy and the first time a government has adopted a whole of government approach to ICTs. This article provides a personal view of the policy process for creating the Digital Strategy, presented by one of the participants...

This paper will discuss recent initiatives to encourage the development of broadband networks in New Zealand. It is widely believed that the availability of good quality broadband will lead to improved economic development at the regional level. This paper considers the role played by both national and regional government in improving access to broadband. At a national level the government has ...

Organizations are increasingly adopting digital strategies and investing heavily in digital technologies and initiatives. However, to date, there does not appear to be a clear understanding of digital strategies and their purpose, which forms the motivation for this research. This research-in-progress study aims to address this research gap by exploring 1) the various conceptions of digital str...

•Many parents use multiple monitoring strategies in different combinations over time to monitor their adolescents.•Adolescents of parents who use multiple strategies reported greater risk involvement.•Parents who solicited information only from adolescents had greater knowledge and adolescent disclosure.

Nucleotide-binding and oligomerization domain-containing protein 1 (NOD1) and NOD2 are cytosolic pattern-recognition receptors (PRRs) composed of an N-terminal caspase activation and recruitment domain (CARD), a central NACHT domain and C-terminal leucine-rich repeats (LRRs). They play a vital role in innate immune signaling by activating the NF-κB pathway via recognition of peptidoglycans by L...

BACKGROUND The quality of epilepsy care has often been noted to be poor and fragmentary. Most people with epilepsy are solely under the care of their general practitioner (GP). Many patients report medication side-effects and poor seizure control. Most GPs accept responsibility for epilepsy care; however, many report problems with knowledge of epilepsy and nearly all support guidance on epileps...