SUMMARY The exfoliative cytology of the lung was studied during the induction and early development of respiratory tract tumors. Syrian golden hamsters received multiple intra tracheal injections of benzo(a)pyrene-Fe203 for 14 weeks at a cumulative dose of 45 mg benzo(a)pyrene. Shortly after start of the experiment a severe, probably toxic, cytological response to the carcinogen application was...

The general nature of the carcinogenic process induced by chemicals and radiat ion can be conceived of as a release of the cell from normal intrinsic and extrinsic growth controls through (a) an act ivat ion of a latent virus or the formation of a virus, or (b) a heritable change resulting from reactions between the carcinogen and critical physiological entries. Such concepts may correspond to ...

normal 0 false false false en-us x-none ar-sa background: this study was aimed to evaluate protective and therapeutic effects of a specific mixture, containing vitamin c, lysine, proline, epigallocatechin gallate and zinc, as well as alpha-1-antitrypsin protein on lung tumorigenesis induced by benzo(a) pyrene (b (a) p) in mice. materials and methods: swiss albino mice were divided into two main...

from the right side of the rat were used to determine the radioactivity contained within the mammary teat, fat pad, and vascular areas, while those from the left side were separated into parenchymal cell and fat cell fractions. The intracellular lipid of the parenchymal cells was extracted and quantitated. Although the pattern of carcinogen uptake and clearance by the parenchymal cell intracell...

Tumors have been induced frequently in the laboratory mouse following exposure to the carcinogenic hydrocarbons (6). In many of these studies, the chemicals were applied continuously and at a relatively high concentration. Cramer and Stowell (5) compared the tumorigenic effectiveness of e0-methylcholanthrene when applied continuously or discontinuously to the skin of mice and concluded that ski...

When administered prior to or at the time of carcinogen exposure, the phenolic antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) are effective inhibitors of carcinogenesis in several target organs. However, chronic, postcarcinogen administration of BHT apparently enhances tumorigenesis in certain animal models for liver and lung cancer. The present study was perform...