Throughout the years, the main focus of the research activity was the applicability of different types of carboxyvinyl polymer, commercially available as Carbopols. Given the fact that the PhD thesis focused mostly on development of cutanous gel formulations, based on two traditional (Carbopol 940 and Carbopol 980) and one newly developed carboxyvinyl-type polymer (Ultrez 10), further research ...

The aim of this study was to assess the influence of qualitative and quantitative base composition on pharmaceutical availability of metronidazole. Hydrogels contain water dispersion of 2% Carbopol 971P and various concentration of glycerol, polyethylene glycol and propylene glycol were preparated. Produced formulations were neutralized to the pH 6.0-6.5 with triethanolamine, and metronidazole ...

PURPOSE β-Limit dextrin has been studied for many years as a means to investigate the internal structures of amylose and amylopectin. However its role as an excipient in the pharmaceutical industry has never been reported. This paper is the first one in a series to explore its potential use as an excipient to aid drug delivery. METHODS The bioadhesive properties of β-limit dextrin were studie...

The main aim of the present research was to encapsulate mefenamic acid in niosomes andincorporate the prepared niosomes in the carbopol gel base for sustained therapeutic action. Mefenamic acid loaded niosomes were prepared by thin film hydration technique and evaluated for entrapment efficiency, vesicular size and zeta potential. The entrapment efficiency of the prepared niosomes was found to ...

The objective of present work was to formulate and evaluate Fluconazole (FLZ) microsponges using quasi emulsion solvent diffusion technique and microsponge gel by using carbopol. Microsponges containing FLZ were obtained successfully with different proportions of ethyl cellulose polymer (EC). The formulations were studied for particle size and physical characterization. The physical characteriz...

Rifampicin biodegradable microcapsules were prepared by feasible emulsification-ionic gelation method for a novel controlled release product. Sodium alginate and Carbopol 974P were used as coating polymers in different ratios 1:1, 1:2, 1:3 and 1:4 to obtain elegant microcapsules. The formulations were characterized for encapsulation efficiency, drug loading, sieve analysis, scanning electron mi...

Carbomers are carboxyvinylic derivatives that are widely used in the manufacture of hydrogel dosage forms. Because of their anionic nature and large number of acid groups, they tend to interact with cationic substances, and with other hydrophilic polymers containing alcohol groups. Here, we report a study of interactions between the carbomer Carbopol and the cationic drug propranolol hydrochlor...

Oral mucoadhesive dosage formulations reveal numerous advantages they offer, like easy application, discrete handling and no need to swallow the drug product. Nevertheless, in order ensure correct performance of these preparations, must show suitable physicochemical properties, such as sorption wetting, viscosity adhesion mucous membrane. In this study, properties selected polymers their blends...