Carbon monoxide belongs to the family of signaling molecules and has been shown to possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing CO-based therapeutics. Herein we report a "click and release" CO-prodrug approach, which allows the release of CO under physiological conditions without the need for light irradiation. The system releases CO in a triggere...

Background Besides nitric oxide, carbon monoxide (CO) also activates soluble guanylyl cyclase (sGC). CO as well as the CO-donor CORM-2 have been shown to possess vasodilatory properties. Whether these vasodilatory properties by CO can be attributed to sGC activation is still a matter of debate. The aim of this study was to examine the involvement of sGC and its different subunits in CO and CORM...

Reaction between a β-diketiminato magnesium hydride and carbon monoxide results in the isolation of a dimeric cis-enediolate species through the reductive coupling of two CO molecules. Under catalytic conditions with PhSiH3 , an observable magnesium formyl species may be intercepted for the mild reductive cleavage of the CO triple bond.

The coadsorption of D2O and CO on Rh(100) under ultrahigh vacuum has been investigated by using infrared reflection absorption spectroscopy. The results show that the presence of D2O induces partial displacement of the CO molecules from linear to bridged configurations. The resulting spectra are very similar to those observed at equivalent CO coverages in an electrochemical environment. The spe...

Sum frequency generation and IR absorption spectra of CO adsorbed on Pd(111) are reported. Adsorption of CO in the surface temperature range 150–230 K results in the appearance of extra peaks in the spectral range of the CO stretching vibration. The conditions of appearance of these peaks, and their stability, are investigated. The extra peaks are assigned to sites at antiphase domain boundarie...

A coumarin-based fluorogenic probe, PCO-1, senses carbon monoxide (CO) selectively in HEPES buffer at pH 8.0 through the intramolecular cyclization-elimination pathway based on Pd(0) mediated reaction. The probe exhibits a 'turn-on' response of CO over a variety of relevant reactive oxygen, nitrogen and sulfur species.

In purchasing fresh retail meat, the microbiological shelf life, color and general appearance are important features to the consumers. Underlying these features, food safety and product confidence has been increasingly emphasized. Growth of spoilage and pathogenic bacteria is generally reduced by stringent hygienic standards, low storage temperatures and by using modified atmospheres packaging ...

in this study, a new array of meteorological elements and a synoptic climatologic classification to produce abaseline climate and to derive meteorological factors that are effective on air pollution in tehran, which is located in a semi-enclosed basin was developed. the data set includes daily sea-level pressure and 500mb geopotential height fields from ncep-ncar and tehran upper air sounding d...

Background The measurement of exhaled carbon monoxide (CO) level may provide an immediate, noninvasive method of assessing smoking status. In addition CO is a molecule generally presumed to be a marker of oxidative stress and inflammation when endogenously produced. Many reports have focused on increased endogenous CO production in pulmonary diseases, including asthma and COPD. The purpose of o...