In the RuCl2(p-cymene)/PPh3 catalysed regioselective allylic alkylation of monosubstituted allyl acetates with malonate anion, the selective substitution at the position originally substituted with acetate was observed.

In the injured spinal cord, chondroitin sulfate proteoglycans (CSPGs) are the principal responsible of axon growth inhibition and they contribute to regenerative failure, promoting glial scar formation. Chondroitinase ABC (chABC) is known for being able to digest proteoglycans, thus degrading glial scar and favoring axonal regrowth. However, its classic administration is invasive, infection-pro...

This work aims to develop carbomer (934, 0.25%) loaded polydatin nanocrystals hydrogel (Pol-NaH) as a novel dermal formulation..Polydatin nanocrystals were prepared by high pressure homogenization technique, applying 1500 bar up to 15 cycles. The long-term storage stability of Pol-NaH was studied after stored at room temperature for 180 days. The physicochemical characteristics of Pol-NaH were ...

The aim of the study was to develop and physicochemicaly characterize single unit controlled delivery system of Theophylline and was formulated as floating matrix tablet by direct compression method using gas generating agent (sodium bicarbonate) and various viscosity grades of hydrophilic polymers (HPMC K15M, K4M; HPC and Carbapol 934P). Formulation was optimized on the basis of buoyancy and i...

The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and intranasal absorption of fexofenadine hydrochloride (FXD HCl). The prepared gels were characterized by gelation temperature, viscoelasticity, and d...

Previously microspheres containing metformin hydrochloride were prepared by using two different methods viz. ionotropic gelation and solvent evaporation method. In this study, acute toxicity studies were investigated in male albino rats following oral administration of the microspheres. The rats were carefully observed for any clinical signs for seven days, and gross observations of the organs ...

A new drug delivery system for H2 receptor antagonist Ranitidine hydrochloride, was developed utilizing both the concepts of adhesiveness and of flotation, in order to obtain a unique drug delivery system which could remain in the stomach for a much longer period of tim Floating-Mucoadesive tablets of Ranitidine hydrochloride were developed to prolong its release and improve bioavailability. Ra...

The purpose of present investigation was to develop and optimize bucco mucoadhesive bilayered tablets of Propranolol hydrochloride (PrHCL) using the bioadhesive polymers hydroxyl propyl methyl cellulose (HPMC K4M), xanthan gum (XG) and acrypol 934P (AL-P) individually and in combination along with ethyl cellulose (EC) as an impermeable backing layer. The 3 full factorial design was employed by ...

A mucoadhesive drug delivery system for systemic delivery of nitrendipine, a calcium channel blocker through buccal route was formulated. Mucoadhesive polymers like hydroxypropylmethylcellulose K-100, hydroxypropylcellulose, sodium carboxymethylcellulose, sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone K-30 and carbopol-934P were used for film fabrication. The films were evaluated for...