1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), a persistent environmental contaminant, is a metabolite of the pesticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). DDE is similar to phenobarbital (PB) in that both compounds are inducers of rat hepatic cytochrome P450 2B and 3A (CYP 2B and 3A). The induction of CYP 2B and 3A by PB is known to be regulated through the nuclear recept...

BACKGROUND Depressed mood following an acute coronary syndrome (ACS) is a risk factor for future cardiac morbidity. Hypothalamic-pituitary-adrenal (HPA) axis dysregulation is associated with depression, and may be a process through which depressive symptoms influence later cardiac health. Additionally, a history of depression predicts depressive symptoms in the weeks following ACS. The purpose ...

This paper proposes a rule-based car-following model to simulate the driver decision process and model the associated vehicle longitudinal action in the car-following regime. In order to analyze individual driver characteristics and extract driving behavior rules, a fuzzy rule based neural network is constructed with the objective of presenting driver action rules under the associated traffic s...

Cognitive dysfunction caused by some neurodegenerative diseases is associated with an increased risk of traffic accidents. Previous studies have reported inconsistent results for prodromal and early stages of dementia. Few studies have directly compared the effects on driving performance of amnestic subtype of mild cognitive impairment (aMCI) with those by normal aging in elderly drivers. The p...