We describe a Newton-based nonlinear solver for immiscible two-phase transport in the presence of significant viscous, buoyancy, and capillary forces. The evolution of CO2 plumes in heterogeneous saline aquifers, especially during the post-injection period, is an important example of this class of problem. The flux (fractional flow) function, which is strongly nonlinear function of saturation, ...

The distribution of red blood cells in alveolar capillaries is typically nonuniform, as shown by intravital microscopy and in alveolar tissue fixed in situ. To determine the effects of red cell distribution on pulmonary diffusive gas transport, we computed the uptake of CO across a two-dimensional geometric capillary model containing a variable number of red blood cells. Red blood cells are spa...

We derive transport equations for the propagation of water wave action in the presence of subsurface random flows. Using the Wigner distribution W(x, k, t) to represent the envelope of the wave amplitude at position x, time t contained in high frequency waves with wave vector k/ε (where ε is a small parameter compared to a characteristic distance of propagation), we describe surface wave transp...

Conditionally immortalized brain and retinal capillary endothelial and choroid plexus epithelial cell lines were established from a transgenic rat (Tg rat) and mouse (Tg mouse) harboring the temperature-sensitive simian virus 40 (ts SV 40) large T-antigen. These cell lines exhibit temperature-sensitive cell growth due to the expression of ts SV 40 large T-antigen. Mouse brain (TM-BBB) and rat b...

It is generally presupposed that the shapes and mechanisms encountered in nature have evolved in such a way as to maximize the robustness of a species. However, most such optimization problems arising in biology are sufficiently complex that it is neither clear what is being optimized, nor what are the relevant constraints. We here consider a number of natural fluid transport systems that may b...

Caveolae are Omega-shaped vesicular structures postulated to play a role in transvascular protein transport. Studies on mice lacking endothelial caveolae, caveolin-1 knockout (Cav-1-KO) mice, indicate increased macromolecular transport rates. This was postulated to be due to the appearance of an alternative pathway. The present study tested whether an alternative pathway had appeared in Cav-1-K...

A mesoscopic or coarse-grained approach is presented to study thermo-capillary induced ows. An order parameter representation of a two-phase binary uid is used in which the interfacial region separating the phases naturally occupies a transition zone of small width. The order parameter satisses the Cahn-Hilliard equation with advective transport. A modiied Navier-Stokes equation that incorporat...

A detailed model of red blood cell (RBC) transport in a capillary network is an indispensable element of a comprehensive model for the supply of the human organism with oxygen and nutrients. In this paper, we introduce a two-phase model for the perfusion of a capillary network. This model accounts for the special role of RBCs, which have a strong influence on network dynamics. Analytical result...

Capillaries were isolated from bovine retina by homogenization and glass bead filtration in order to study their ability to transport certain solutes. Viability of the microvessels was demonstrated by their ability to maintain linear rates of substrate oxidation for more than two hours. He.uose uptake (measured using 3-o-methyl-D-glucose) could be inhibited b3 cytochalasin R, phloretin and phlo...

This study investigated the role of a multispecific organic anion transporter, Oatp1a4/Slco1a4, in drug transport across the blood-brain barrier. In vitro transport studies using human embryonic kidney 293 cells expressing mouse Oatp1a4 identified the following compounds as Oatp1a4 substrates: pitavastatin (K(m) = 8.3 microM), rosuvastatin (K(m) = 12 microM), pravastatin, taurocholate (K(m) = 4...