BACKGROUND Right ventricular failure from increased pulmonary vascular loading is a major cause of morbidity and mortality, yet its modulation by disease remains poorly understood. We tested the hypotheses that, unlike the systemic circulation, pulmonary vascular resistance (R(PA)) and compliance (C(PA)) are consistently and inversely related regardless of age, pulmonary hypertension, or inters...

W HEN radioactive krypton (Kr 85), a beta-emitting radioisotope, is introduced into the circulation, it does not act as a simple intravaseular indicator. As this substance, in solution in the blood stream, traverses the systemic capillary bed, it diffuses freely into the interstitial and intra-cellular spaces. When blood containing Kr 85 passes through the pulmonary capillary bed, approximately...

Systemic sclerosis (SSc) is a chronic connective tissue disorder characterized by widespread microangiopathy, fi brosis, and autoimmunity that aff ects the skin and internal organs. Although in SSc there is a lack of suffi cient angiogenic response to chronic tissue ischemia culminating in the loss of capillary vessels, the expression of vascular endothelial growth factor-A (VEGF) has paradoxic...

Purpose: To study peripapillary retinal capillary circulation in eyes treated with iodine 125 (I) plaque brachytherapy for uveal melanoma using optical coherence tomography angiography (OCTA). Design: Cross-sectional study of 10 participants imaged with OCTA before uveal melanoma treatment and 15 participants imaged after development of radiation retinopathy, optic neuropathy, or both. Particip...

References HAMPTON, J.R. & MITCHELL, M.R.A. (1966) Abnormalities of platelet behaviour in acute illness. British Medical Journal, 51, 1079 JAN, KUNG-MING, CHIEN, SHU & BIGGER, J.T., JR (1975) Observations on blood viscosity changes after myocardial infarction. Circulation, 51, 1079. KASABACH, H.H. & MERRITT, K.K. (1940) Capillary hemangioma with extensive purpura. American Journal of Diseases o...

Pulsating electrostatic field (PESF) therapy was investigated to assess the possibility of increasing the resting metabolic rate (RMR) in 14 adult females. The pumping effect of positive calcium and hydrogen ions was obtained by 30 min daily exposure to negative PESF, adjusted individually between 2 and 9 kV. This treatment could result in a buffering effect on blood pH and reduction of the rou...

By means of an intracellular capillary electrode the effects of barium chloride on the resting and action potentials of ventricular fibers of the frog were recorded in hearts with circulation intact and hearts isolated and perfused. The changes were essentially similar in both preparations. The major change observed was a statistically significant (p < 0.01) increase in duration of the action p...

The mesangium is more than simply a support structure for glomerular capillary circulation. Mesangial cells respond to various vasoactive mediators and probably contribute to the regulation of mesangial cell contractility and, consequently, glomerular perfusion. The surrounding extracellular matrix contains several glycoproteins and collagens that may affect the immune interactions of antigens ...

• In the microcirculation of the renal cortex, fluid exchange proceeds at very high rates in two anatomically and functionally distinct capillary systems, the glomerular and the peritubular capil-laries. Net ultrafiltration is confined to the glomeru-lus, which consists of a tuft of capillaries surrounded by the ultrafiltrate enclosed within Bowman's capsule at the proximal end of the nephron. ...