نتایج جستجو برای: cap oseltamivir
تعداد نتایج: 24776 فیلتر نتایج به سال:
BACKGROUND The Taiwan CDC provided free oseltamivir to all patients with influenza infections confirmed by rapid testing or who had clinical warning symptoms during the 2009 H1N1 influenza pandemic in Taiwan. However, oseltamivir utilization patterns, cost, and outcomes among oseltamivir-treated patients remained unclear. METHOD A population-level, observational cohort study was conducted usi...
A 2008 review by our group concluded that the risk of neuropsychiatric adverse events (NPAEs) in influenza patients was not increased by oseltamivir exposure, and did not identify any mechanism by which oseltamivir or its metabolites could cause or worsen such events. The current article reviews new information on this topic. Between September 16, 2007 and May 15, 2010, 1,805 spontaneously-repo...
Methods: Data from a total of 96 subjects, who received various dosages of oral and i.v. oseltamivir either in singleor repeated-dose regimens in four separate studies, and for whom rich PK data was available, were used for the development of the oseltamivir population PK model. Single dose data from 19 subjects in a fifth study, which included an OP arm and an OP + probenecid arm, were used to...
We describe laboratory-confirmed influenza A pandemic (H1N1) 2009 in 17 hospitalized recipients of a hematopoietic stem cell transplant (HSCT) (8 allogeneic) and in 15 patients with malignancy treated at 6 Australian tertiary centers during winter 2009. Ten (31.3%) patients were admitted to intensive care, and 9 of them were HSCT recipients. All recipients of allogeneic HSCT with infection <100...
The neuraminidase (NA) of the influenza virus is the target of antiviral drug, oseltamivir. Recently, cases are reported that Influenza virus becoming resistant to oseltamivir, necessitating the development of new long-acting antiviral compounds. Most importantly, H274Y mutation in neuraminidase exhibits high levels of resistance to oseltamivir. In this report, a novel class of lead molecule wi...
Sir, the emergence of H7N9 bird flu in China presents an interesting situation1. The World Health Organization notes the importance of monitoring this situation for a potential worldwide pandemic2. In terms of the disease, H7N9 bird flu is an atypical influenza virus infection and the drug treatment is oseltamivir. There is great concern surrounding the adverse effects of oseltamivir. “Delirium...
The viral surface glycoprotein neuraminidase (NA) allows the influenza virus penetration and the egress of virions. NAs are classified as A, B, and C. Type-A NAs from influenza virus are subdivided into two phylogenetically distinct families, group-1 and group-2. NA inhibition by oseltamivir represents a therapeutic approach against the avian influenza virus H5N1. Here, structural bases for ose...
To the Editor: We previously reported detection of double resistance to oseltamivir and amantadine of influenza virus A (H1N1) in Hong Kong during the first half of 2008 (1). Three different strains of A/Hong Kong/2652/2006-like (clade 2C) viruses that carried the S31N mutation in the matrix (M2) gene associated with amantadine resistance acquired a neuraminidase (NA) gene with CAT→TAT change a...
CONTEXT Influenza virus is easily spread among the household contacts of an infected person, and prevention of influenza in household contacts can control spread of influenza in the community. OBJECTIVE To investigate the efficacy of oseltamivir in preventing spread of influenza to household contacts of influenza-infected index cases (ICs). DESIGN AND SETTING Randomized, double-blind, place...
BACKGROUND Resistance to drug therapy, along with high rates of metastasis, contributes to the low survival rate in patients diagnosed with pancreatic cancer. An alternate treatment for human pancreatic cancer involving targeting of Neu1 sialidase with oseltamivir phosphate (Tamiflu®) was investigated in human pancreatic cancer (PANC1) cells with acquired resistance to cisplatin and gemcitabine...
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