Prevention of implant-associated infections has been one of the main challenges in orthopaedic surgery. This challenge is further complicated by the concern over the development of antibiotic resistance as a result of using traditional antibiotics for infection prophylaxis. The objective of this study was to develop a technique that enables the loading and local delivery of a unique group of ca...

Aristoteles (384-322) verwendete den Begriff „geometrische Analogie“ zur Beschreibung der Gleichheit zweier quantitativer oder qualitativer Verhältnisse [Co02]. Beispiele: „1 verhält sich zu 2 wie 5 zu 10“ oder „Die Federn sind für den Vogel, was die Schuppen für den Fisch sind“. Eine informatische Modellierung beginnt manchmal mit der Formulierung qualitativer geometrischer Analogien. Ein Beis...

Previously we reported that calcium phosphate nanoparticles (CAP) represented a superior alternative to alum adjuvants in mice immunized with viral protein. Additionally, we showed that CAP was safe and elicited no detectable immunoglobulin E (IgE) response. In this study, we demonstrated that following mucosal delivery of herpes simplex virus type 2 (HSV-2) antigen with CAP, CAP adjuvant enhan...

BACKGROUND We hypothesized that obstructive sleep apnea (OSA) can predispose individuals to lower airway infections and community-acquired pneumonia (CAP) due to upper airway microaspiration. This study evaluated the association between OSA and CAP. METHODS We performed a case-control study that included 82 patients with CAP and 41 patients with other infections (control group). The controls ...

Growing microtubules are protected from depolymerization by the presence of a GTP or GDP/Pi cap. End-binding proteins of the EB1 family bind to the stabilizing cap, allowing monitoring of its size in real time. The cap size has been shown to correlate with instantaneous microtubule stability. Here we have quantitatively characterized the properties of cap size fluctuations during steady-state g...

Because most sediment contaminants are highly sorptive, their migration through a cap is retarded due to transient accumulation on the clean cap material. Thus the time for typical sediment contaminants to migrate through a cap can be hundreds or thousands of years if the cap is designed and maintained to retain its integrity throughout that period. Effective design of a cap to isolate contamin...

Many say the market for the shares of smaller companies—so called small-cap and mid-cap stocks—offers greater opportunity for active management to add value than does the large-cap market. The underlying notion is that the market for small and medium caps is less efficient than the large-cap market, and, therefore, security mispricing is more prevalent there. It is true that fewer securities an...

To determine the mechanism(s) underlying enhanced oxidative stress in kidneys of salt-sensitive hypertension, neonatal Wistar rats were given vehicle or capsaicin (CAP, 50 mg/kg sc) on the first and second days of life. After being weaned, male rats were assigned into four groups and treated for 2 wk with the following: vehicle + a normal sodium diet (NS, 0.4%, CON-NS), vehicle + a high-sodium ...

We have isolated 21 mutants of catabolite gene activator protein (CAP) defective in transcription activation at the lac promoter but not defective in DNA binding. The amino acid substitutions in the mutants map to a single region of CAP: amino acids 156-162. As assessed in vito, the substituted CAP variants are nearly completely unable to activate transcription at the lac promoter but bind to D...

Six Candida spp. that were previously characterized for cutaneous pathogenicity were assessed for Candida acid proteinase (CAP) production in albumin-supplemented, nitrogen-restricted media. C. albicans CAP production was compared in media supplemented with albumin, casein, collagen, hemoglobin, or keratin and in TC medium 199. C. albicans, C. stellatoidea, and C. tropicalis, which are cutaneou...