The location of autocrine interactions between the v-sis protein and PDGF receptors remains uncertain and controversial. To examine whether receptor-ligand interactions can occur intracellularly, we have constructed fusion proteins that anchor v-sis to specific intracellular membranes. Fusion of a cis-Golgi retention signal from a coronavirus E1 glycoprotein to v-sis protein completely abolishe...

Recognition that the sis gene codes for a protein homologous with at least one of the two chains of platelet-derived growth factor has made it possible to directly assess transcriptional expression of platelet-derived growth factor both in cultured cells and in tissue obtained in vivo. We have found that a 3.7-kilobase RNA homologous to the sis gene is expressed at moderate levels in cultured h...

Nonbiased V gene usage for V(D)J joining is essential for providing an optimal immune system, but no cis-acting sequence with this function has been uncovered. We previously identified a recombination silencer and heterochromatin targeting element in the Vκ-Jκ intervening sequence of germline Igκ transgenes, which we termed Sis. We now have generated Sis knockout mice in the endogenous locus. I...

BACKGROUND Published methods for quantification of magnetic resonance imaging (MRI) evidence of inflammation in the sacroiliac joint lack validation in pediatric populations. We evaluated the reliability and construct validity of the Spondyloarthritis Research Consortium of Canada (SPARCC) sacroiliac joint inflammation score (SIS) in children with suspected or confirmed juvenile spondyloarthrit...

BACKGROUND Patients with subacromial impingement syndrome (SIS) commonly seek primary care. Subacromial corticosteroid injection is the standard treatment given by GPs, which is supported by earlier studies reporting a positive effect but inconclusive evidence over the long- term. In Sweden, physiotherapists often choose acupuncture combined with exercises to treat SIS, which was reported as pr...

Background The ChatGPT is an artificial intelligence chatbot that processes natural language text learned through reinforcement learning based on the GPT-3.5 architecture, a large-scale model. Natural processing models are being used in various fields and gradually expanding their use medical field. Purpose This study aimed to investigate information treatment options can provide for shoulder i...

In this paper, The impulsive delay epidemic SIS model is considered. By using the continuation theory for k-set contractions, the sufficient conditions of the existence of positive ω−periodic solutions of the impulsive delay SIS model are obtained.