In magnetic nanoparticle hyperthermia treatment, the ideal objective is to destroy all tumor cells without any damage to neighboring normal tissues. Thus, the temperature distribution in cancerous tissue and also surrounding healthy tissues should become closer to the desired distribution. In this paper, the temperature distribution is estimated by using a numerical scheme to solve the Penne’s ...

We previously established an in vitro cellular carcinogenesis model of oral squamous cell carcinoma (OSCC) with a line of human immortalized oral epithelia cells (HIOECs), a line of cancerous HB96 cells, and other cells (HB56 cells) at the early stage of carcinogenesis. In this study, comparative proteomic analysis identified a panel of differentially expressed proteins among these cells, and S...

The currently used techniques for the detection of esophageal cancer usually rely on pathological examination after sectioning and ultrasound imaging. Optical methods have the advantages of better spatial resolution and sensitivity with minimal invasion. Therefore, the development of optical techniques will be helpful for the diagnosis of esophageal cancer at the early stage. In this research, ...

In this work, the potential use of nanoparticles as contrast agents by using spectral domain optical coherence tomography (SD-OCT) in liver tissue was demonstrated. Gold nanoparticles (average size of 25 and 70 nm), were studied in human normal and cancerous liver tissues in vitro, respectively. Each sample was monitored with SD-OCT functional imaging for 240 min. Continuous OCT monitoring show...

Target molecules for a highly sensitive and specific diagnosis of breast cancer in its early clinical stages have not yet been identified. Here, we show the first evidence for diagnostic performance of the molecule B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) in breast cancer patients. Only 5 out of 46 non-cancerous samples were positive for Bmi-1 mRNA expression res...