background glioblastoma is a type of brain tumor with poor response to available therapies, and shows high rate of mortality. despite remarkable advancements in our knowledge about cytogenetic and pathophysiologic features of glioblastoma, current treatment strategies are mainly based on cytotoxic drugs; however, these therapeutic approaches are facing progressive failure because of the resista...

Background and objectives: Because of the importance of breast cancer as a first cause of morbidity and mortality among females, also the limitation of chemotherapy and based on literature of the use of herbal medicines against cancer, the current study was aimed to determine the efficacy of Berbers vulgaris fruit ethanol extract against MCF-7 breast cancer cell line. ...

a new series of 1,2-diaryl-4,5,6,7-tetrahydro-1h-benzo[d]imidazoles, possessing trimethoxy phenyl pharmacophore, were synthesized to evaluate their biological activities as tubulin inhibitors. cytotoxic activity of the synthesized compounds 7a-f was assessed against several human cancer cell lines, including mcf-7 (breast cancer cell), hepg2 (liver hepatocellular cells), a549 (adenocarcinomic h...

Background: Evaluation of cell viability is momentous in pharmacologic and oncological research. Cell viability evaluation determines cell sensitivity and consequently treatment outcome. Various methods are available to determine cell survival. Each of these methods evaluates different endpoints. Accordingly, determining the correlation between these methods is important. In this study, in orde...

The treatment of prostate cancer patients usually starts with androgen ablation and followed by chemotherapy; however, in some cases the tumor develops resistant phenotype. Combination therapy is currently regarded as a cornerstone in cancer therapy to overcome the drug resistance. Herein, we investigated the combinatory effect of Docetaxel and Trastuzumab with a novel nanomedicine, BCc1. Also,...

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as Aspirin may have anticancer properties, and can be effective as a novel strategy for the treatment of colorectal cancer (CRC). The aim of this study was to assess the cytotoxic effects of Aspirin drug in CRC cell lines compared with Oxaliplatin drug in vitro. Methods: Cell viability was assessed after treatment of SW742 and SW48...

Background: Liver cancer is the second outstanding reason for cancer-related death global and thus a main public health challenge. Plant-based drugs are regarded as promising therapies. Basil and Dracocephalum kotschyi extracts have shown therapeutic impacts on various cancers. Therefore, we assessed the effects of the extract of Basil and Dracocephalum kotschyi on cell proliferation and BCL2 e...

Objective(s): Berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis are not well known. Cancer cells obtain the ability to change their chemokine system and convert into metastatic cells. In this study, we examine...