Canavan's disease (CD) is a fatal autosomal recessive pediatric leukodystrophy in which patients show severe neurodegeneration and typically die by the age of 10, though life expectancy in patients can be highly variable. Currently, there is no effective treatment for CD; however, gene therapy seems to be a feasible approach to combat the disease. Being a monogenic defect, the disease provides ...

Background: Effective treatment of Rheumatoid arthritis (RA) patients is achievable within a short window opportunity following diagnosis. T-cells are early drivers synovial inflammation RA, therefore, identification pathogenic T-cell subsets at the tissue pre-RA, arthralgia subjects, would greatly improve our understanding disease pathogenesis. Comparative analysis healthy control, subject and...

Background: Rheumatoid arthritis (RA) is a progressive erosive autoimmune disease that affects 1% of the world population. Anti-citrullinated protein autoantibodies (ACPA) are routinely used for diagnosis RA, however 20-30% patients ACPA negative. status delineator RA endotypes with similar clinical manifestation but potentially different pathophysiology. Elucidating underlying mechanisms patho...

1 Brian Canavan, University of Glasgow, Robert Clark Centre for Technological Education, 66 Oakfield Avenue, Glasgow [email protected] 2 Jane Magill, University of Glasgow, Robert Clark Centre for Technological Education, 66 Oakfield Avenue, Glasgow [email protected] 3 David Love, University of Glasgow, Robert Clark Centre for Technological Education, 66 Oakfield Avenue, Glasgow d....

Received: November 22, 2013 Accepted: December 26, 2013 Published: January 03, 2014 neurons, astrocytes and oligodendrocytes is vital for normal brain function [1]. As such it has been described as the brain’s “operating system” [2]. NAA is synthesized by neurons from acetyl co-enzyme A (AcCoA) with the acetyl group derived from on-going oxidation of glucose (Glc), and from L-aspartate (Asp). N...